College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, Jiangxi, 341000, China; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Ganan Medical University, Ganzhou, 341000, China.
School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, 330031, China.
Cell Calcium. 2019 Jun;80:25-28. doi: 10.1016/j.ceca.2019.03.005. Epub 2019 Mar 14.
Briefly review the recent structural work of transient receptor potential canonical (TRPC) ion channels by using electron cryo-microscopy (cryo-EM). The high resolution structures of TRPC3, TRPC4, TRPC5 and TRPC6 are discussed.
简要综述利用电子冷冻显微镜(cryo-EM)研究瞬时受体电位经典型(TRPC)离子通道的近期结构研究进展。讨论了 TRPC3、TRPC4、TRPC5 和 TRPC6 的高分辨率结构。