Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Department of Neonatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Am J Perinatol. 2021 Feb;38(3):258-264. doi: 10.1055/s-0039-1696715. Epub 2019 Sep 6.
Breast milk (BM) contains antioxidant molecules which may offer protection against oxidative stress (OS). We aim to investigate oxidant-antioxidant balance in preterm BM during the course of lactation and within a nursing session.
Total antioxidant capacity (TAC) and total oxidant status (TOS) were measured in colostrum, transitional, and mature BM samples of preterm infants born earlier than 34th week of pregnancy and healthy term infants. Oxidative stress index (OSI) was calculated. Foremilk and hindmilk samples were collected separately.
In colostrum and transitional milk, TAC ( < 0.001 and = 0.001, respectively) and TOS ( = 0.005 and < 0.001, respectively) were lower in preterm BM compared with term BM. OSI was also lower in preterm BM, but it was statistically significant only in transitional milk ( < 0.001). TAC was highest in colostrum and decreased through the course of lactation. However, the decrease in TAC was not statistically significant in preterm BM. Lowest values of TOS and OSI were observed in colostrum. In transitional term BM, hindmilk had a better oxidant-antioxidant profile as indicated by lower TOS and OSI.
Oxidant-antioxidant balance is preserved in BM in every stage of lactation. Preterm BM has lower OSI which may offer benefits to preterm newborn against OS.
母乳（BM）中含有抗氧化分子，可能对氧化应激（OS）提供保护。我们旨在研究早产儿 BM 在哺乳期和哺乳过程中的氧化剂-抗氧化剂平衡。
我们测量了早于 34 孕周出生的早产儿和健康足月婴儿的初乳、过渡乳和成熟乳样本中的总抗氧化能力（TAC）和总氧化状态（TOS）。计算了氧化应激指数（OSI）。我们分别采集前奶和后奶样本。
在初乳和过渡乳中，早产儿 BM 的 TAC（<0.001 和=0.001）和 TOS（=0.005 和<0.001）均低于足月 BM。早产儿 BM 的 OSI 也较低，但仅在过渡乳中具有统计学意义（<0.001）。TAC 在初乳中最高，并随着哺乳期的进行而降低。然而，早产儿 BM 中的 TAC 降低无统计学意义。TOS 和 OSI 的最低值出现在初乳中。在过渡乳中，后奶的氧化剂-抗氧化剂谱更好，表现为 TOS 和 OSI 较低。
在哺乳期的各个阶段，BM 中的氧化剂-抗氧化剂平衡得以维持。早产儿 BM 的 OSI 较低，这可能对早产儿的 OS 提供有益作用。
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