Department of Pharmacy, Laboratory of Molecular Biology & Immunology, University of Patras, 26504 Rio, Greece.
Institute of Physic, Danish Technical University, DK-2800 Kgs Lyngby, Denmark.
Biosensors (Basel). 2019 Sep 5;9(3):107. doi: 10.3390/bios9030107.
Chronic pressure ulcers are hard-to-heal wounds that decrease the patient's quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates and transfers ions that are negatively-charged to the injured tissue, using accessible air gases as a transfer medium. WMCS is capable of generating similar tissue potentials, as electrode-based ES, for injured tissue. Here, through immunohistochemistry, we intended to characterize the induced tissue healing biological mechanisms that occur during WMCS therapy. Two single cases of bedridden due to serious stroke white men with chronic non-healing pressure ulcers have been treated with WMCS technology. WMCS suppresses inflammatory responses by decreasing the aggregation of granulocytes, followed by stimulating myofibroblastic activity and a new formation of collagen fibers, as depicted by immunohistochemistry. As a result, WMCS provides a special adjunct or stand-alone therapy choice for chronic and non-healing injuries, similar to electrode-based ES, but with added (i.e., contactless) benefits towards its establishment as a routine clinical wound healing regime.
慢性压力性溃疡是难以愈合的伤口，会降低患者的生活质量。无线微电流刺激 (WMCS) 是一种创新的、非侵入性的、类似于基于电极的电刺激 (ES) 技术，它利用可及的空气气体作为传递介质，产生并向受损组织传递带负电荷的离子。WMCS 能够为受损组织产生类似于基于电极的 ES 的组织潜能。在这里，我们通过免疫组织化学，旨在描述 WMCS 治疗过程中发生的诱导组织愈合的生物学机制。两名因严重中风而卧床不起的白人男性慢性非愈合性压力性溃疡患者，采用 WMCS 技术进行了治疗。WMCS 通过减少粒细胞聚集来抑制炎症反应，随后刺激肌成纤维细胞活性和新的胶原纤维形成，如免疫组织化学所示。结果，WMCS 为慢性和非愈合性损伤提供了一种特殊的辅助或独立治疗选择，类似于基于电极的 ES，但具有更多的（即非接触式）益处，使其成为常规临床伤口愈合方案。
