重复经气管滴注纳米 In₂O₃ 颗粒到 Wistar 大鼠肺部后的器官分布和损伤。
Organs Distribution and Injury After Repeated Intratracheal Instillations of Nano-In₂O₃ Particles into the Lungs of Wistar Rats.
机构信息
College of Safety Science and Engineering, Nanjing Tech University, Nanjing 210009, Jiangsu, China.
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing 100049, China.
出版信息
J Nanosci Nanotechnol. 2020 Mar 1;20(3):1383-1390. doi: 10.1166/jnn.2020.17173.
Elevated industrial production and broaden applications of indium oxide materials have increased concerns over the occupational exposure of industry workers. Respirable In₂O₃ particles have been identified in the workplaces and lung of indium-processing workers. The aim of this study was to assess the indium distribution and organs injury induced by nano-In₂O₃ particles. More than 50% of nano-In₂O₃ particles were accumulated in the lungs after 8-week exposure period and caused serious pulmonary alveolar proteinosis (PAP) and pneumonia. The migration of nano-In₂O₃ particles from lungs to the other organs was very low and dose not steadily increase the indium burden in those organs except kidney and liver. The repeated intratracheal instillations of nano-In₂O₃ particles into the lungs of Wistar rats were dose-dependent increased the concentrations of serum indium.
随着工业生产的提高和氧化铟材料应用范围的扩大，人们越来越关注工业工人的职业暴露问题。在铟加工工人的工作场所和肺部已经发现了可吸入的 In₂O₃ 颗粒。本研究旨在评估纳米氧化铟颗粒引起的铟分布和器官损伤。经过 8 周的暴露期后，超过 50%的纳米氧化铟颗粒积聚在肺部，导致严重的肺泡蛋白沉积症（PAP）和肺炎。纳米氧化铟颗粒从肺部迁移到其他器官的迁移率非常低，除了肾脏和肝脏外，并不会稳定地增加这些器官中的铟负担。将纳米氧化铟颗粒经气管内反复滴注到 Wistar 大鼠的肺部，会使血清铟浓度呈剂量依赖性增加。
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