心肌梗死/中风带中红细胞 EPA+DHA 水平的调查。

Survey of the erythrocyte EPA+DHA levels in the heart attack/stroke belt.

机构信息

OmegaQuant Analytics, LLC, Sioux Falls, SD, USA; Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA.

OmegaQuant Analytics, LLC, Sioux Falls, SD, USA.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2019 Sep;148:30-34. doi: 10.1016/j.plefa.2019.07.010. Epub 2019 Jul 13.

DOI:10.1016/j.plefa.2019.07.010

PMID:31492431

Abstract

BACKGROUND

The Omega-3 Index (O3I; erythrocyte EPA+DHA as a percent of total fatty acids) is inversely related to risk for cardiovascular disease (CVD). The cardioprotective target O3I is 8%-12%. O3I levels in American regions with high CVD risk are poorly characterized.

PURPOSE

To determine the O3I in individuals participating in a Seafood Nutrition Partnership (SNP) survey in seven US cities in the CVD "belt."

METHODS

Fingerstick blood samples were analyzed for the O3I.

RESULTS

The SNP cohort (n = 2177) had a mean (SD) O3I of 4.42% (1.12%). Only 1.2% were in the desirable range, whereas 42% had an undesirable (<4%) O3I. The mean (SD) O3I in a subset of 772 SNP subjects who were matched for age and sex with the Framingham study was 4.6% (1.2%) compared 5.3% (1.6%) in the Framingham cohort (p < 0.0001).

CONCLUSIONS

Individuals in the CVD "belt" had relatively low O3I levels. Since in other settings, a low O3I is associated with increased risk for CVD, this may be one factor contributing to the higher risk for CVD in this region of the US.

摘要

背景

ω-3 指数（O3I；红细胞 EPA+DHA 占总脂肪酸的百分比）与心血管疾病（CVD）风险呈负相关。具有心脏保护作用的 O3I 目标值为 8%-12%。美国心血管疾病风险较高地区的 O3I 水平特征描述较差。

目的

确定参与美国七个 CVD“地带”城市的海鲜营养伙伴关系（SNP）调查的个体的 O3I。

方法

采集指血样本来分析 O3I。

结果

SNP 队列（n=2177）的 O3I 平均值（SD）为 4.42%（1.12%）。只有 1.2%的人处于理想范围，而 42%的人 O3I 不理想（<4%）。在与弗雷明翰研究年龄和性别相匹配的 772 名 SNP 受试者的亚组中，O3I 的平均值（SD）为 4.6%（1.2%），而弗雷明翰队列为 5.3%（1.6%）（p<0.0001）。