Saint Petersburg State University, Universitetskaya nab. 7/9, 199034, St. Petersburg, Russia.
I.V. Grebenshchikov Institute of Silicate Chemistry RAS, Adm. Makarova emb., 2, 199034, St. Petersburg, Russia.
J Biol Inorg Chem. 2019 Oct;24(7):1047-1055. doi: 10.1007/s00775-019-01714-w. Epub 2019 Sep 6.
Detailed crystal chemical characterization of human pathological cardiovascular deposits (PCD) was conducted applying wide set of the instrumental methods (XRD, FTIR, Raman, SEM, different chemical analyses). There was some progress achieved in the understanding of it formation mechanism. The obtained data evidence that pathological cardiovascular deposits are presented by non-stoichiometric water-bearing B-type carbonated hydroxyapatite just like other apatites of the human body. But PCD apatite is characterized by higher concentration of B-type carbonate ion (up to ~ 6 wt%) which leads to the increasing influence of the carbonate-ion on the unit cell parameters in comparison with water and other substitutes. Another difference between PCD apatite and other pathogenic apatites of the human body is the smaller variations of the unit cell parameters, caused by smaller variations of the blood chemical composition. It was shown that apatite on the surface of PCD is characterized by the more non-stoichiometric composition compared to apatite inside these deposits. It is assumed that the formation mechanisms of the PCD apatite and the bone apatite may be similar.
应用一系列仪器方法（XRD、FTIR、拉曼、SEM、各种化学分析）对人体病理性心血管沉积物（PCD）进行了详细的晶体化学表征，对其形成机制有了一定的了解。获得的数据表明，病理性心血管沉积物由非化学计量的含水 B 型碳酸羟基磷灰石组成，就像人体的其他磷灰石一样。但 PCD 磷灰石的 B 型碳酸根离子浓度较高（高达~6wt%），与水和其他取代物相比，这会导致碳酸根离子对单位晶胞参数的影响增大。PCD 磷灰石与人体其他致病磷灰石的另一个区别是，由于血液化学成分的变化较小，单位晶胞参数的变化也较小。研究表明，PCD 表面的磷灰石与这些沉积物内部的磷灰石相比，其组成更非化学计量。据推测，PCD 磷灰石和骨磷灰石的形成机制可能相似。
