衰老与抗衰老研究中的代谢生物标志物。

Metabolic Biomarkers in Aging and Anti-Aging Research.

机构信息

Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.

出版信息

Adv Exp Med Biol. 2019;1178:247-264. doi: 10.1007/978-3-030-25650-0_13.

DOI:10.1007/978-3-030-25650-0_13

PMID:31493231

Abstract

Although human life expectancy has increased significantly over the last two centuries, this has not been paralleled by a similar rise in healthy life expectancy. Thus, an important goal of anti-aging research has been to reduce the impact of age-associated diseases as a way of extending the human healthspan. This review will explore some of the potential avenues which have emerged from this research as the most promising strategies and drug targets for therapeutic interventions to promote healthy aging.

摘要

尽管在过去的两个世纪中，人类的预期寿命显著增加，但健康预期寿命并没有与之同步增长。因此，抗衰老研究的一个重要目标就是减少与年龄相关的疾病的影响，以此来延长人类的健康寿命。这篇综述将探讨一些从该研究中出现的最有前途的策略和药物靶点，这些策略和药物靶点是促进健康衰老的治疗干预措施。