Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, United Arab Emirates.
Department of Obstetrics and Gynecology, Oasis Hospital, Al Ain, United Arab Emirates.
Int J Infect Dis. 2019 Dec;89:96-101. doi: 10.1016/j.ijid.2019.08.031. Epub 2019 Sep 4.
As the current recommendation of administering Tdap (tetanus-diphtheria-acellular pertussis) to all pregnant women has not been widely implemented in the United Arab Emirates (UAE), we aimed to ascertain the prevalence of pertussis seronegativity during pregnancy.
IgG antibodies against Bordetella pertussis toxin (PT) were measured in 213 women attending the antenatal clinic at Oasis hospital, Al Ain, UAE. Results were compared by maternal age, nationality and gestational age with the Kruskal-Wallis test for IgG-PT levels and the Chi-squared test for serology status.
The mean age±SD of the participants was 30.4±5.6 years, mean gestational age±SD of 25.5±3.3 weeks. Serum concentration of IgG-PT <10IU/ml were found in 160 out of 213 women (75%; 95% confidence interval 69%, 81%). There was no significant difference in the geometric mean of serum IgG-PT concentration across maternal age (P=0.80) or nationality (P=0.90). There were no differences in the prevalence of seronegativity with maternal age (P=0.65) or nationality (P=0.90).
With a high prevalence of pertussis seronegativity in pregnant women, there is a potential benefit of introducing pertussis vaccination during pregnancy into our national immunization program.
由于目前向所有孕妇推荐接种 Tdap（破伤风、白喉和无细胞百日咳）的建议尚未在阿拉伯联合酋长国（阿联酋）广泛实施，我们旨在确定妊娠期间百日咳血清学阴性的流行率。
在阿联酋艾因绿洲医院的产前诊所，对 213 名孕妇测量了针对百日咳博德特氏菌毒素（PT）的 IgG 抗体。使用 Kruskal-Wallis 检验比较 IgG-PT 水平，使用卡方检验比较血清学状态，以确定母体年龄、国籍和孕龄对结果的影响。
参与者的平均年龄±标准差为 30.4±5.6 岁，平均孕龄±标准差为 25.5±3.3 周。213 名女性中，有 160 名（75%；95%置信区间 69%，81%）血清 IgG-PT<10IU/ml。血清 IgG-PT 浓度的几何平均值在母体年龄（P=0.80）或国籍（P=0.90）方面无显著差异。血清学阴性的流行率与母体年龄（P=0.65）或国籍（P=0.90）无关。
鉴于孕妇中百日咳血清学阴性的高流行率，在我们的国家免疫计划中引入妊娠期间百日咳疫苗接种可能具有潜在益处。
