Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Curr Opin Cell Biol. 2019 Dec;61:126-131. doi: 10.1016/j.ceb.2019.08.002. Epub 2019 Sep 4.
Biologically oriented regenerative dentistry in an attempt to regrow a functional tooth by harnessing the natural healing capabilities of dental tissues has become a recent trend challenging the current dental practice on repairing the damaged or missing tooth. In this review, we outline the conceptual development on the in situ revitalization of the tooth replacement capability lost during evolution, the updated progress in stem-cell-based in vivo repair of the damaged tooth, and the recent endeavors for in vitro generation of an implantable bioengineered tooth germ. Thereafter, we summarize the major challenges that need to be overcome in order to provide the rationale and directions for the success of fully functional tooth regeneration in the near future.
生物学导向的再生牙科旨在通过利用牙齿组织的自然愈合能力来重新生长功能性牙齿，这已成为当前修复受损或缺失牙齿的牙科实践的一项新挑战。在这篇综述中，我们概述了在原位恢复进化过程中丧失的牙齿替代能力的概念发展，基于干细胞的体内修复受损牙齿的最新进展，以及体外生成可植入的生物工程牙 germ 的最新努力。之后，我们总结了为实现功能性全牙再生的近期成功需要克服的主要挑战，为其提供了基本原理和方向。
