School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
Anal Chim Acta. 2019 Nov 20;1083:137-149. doi: 10.1016/j.aca.2019.06.057. Epub 2019 Jun 29.
Inertial microfluidics is utilized as a powerful passive method for particle and cell manipulation, which uses the hydrodynamic forces of the fluid in the channel to focus particles in specific equilibrium positions in the cross section of the channel. To achieve high performance manipulation, knowledge of focusing pattern of particles in the cross section of channel is essential. In this paper, we propose a method to address this important issue. To this end, firstly inertial microfluidics is analyzed in rectangular cross section channels. The results indicate that fluid flow velocity and channel's cross-sectional profiles have great impacts on the forces exerted on particles. Next, these results are utilized to propose a method to predict equilibrium positions in non-rectangular cross section channels through some simple calculations. This method is based on approximating the velocity profile of a non-rectangular cross section channel by utilizing portions of velocity profiles of different rectangular cross section channels. To analyze the method's performance, results obtained from the proposed method are compared with Direct Numerical Simulation (DNS) and experimental studies of seven non-rectangular channels. It is observed that the proposed approach accurately predicts particles trajectories and their equilibrium positions in the cross section of channels.
惯性微流控技术是一种强大的被动式颗粒和细胞操控方法，它利用通道内流体的动力学力将颗粒聚焦在通道横截面上的特定平衡位置。为了实现高性能的操控，了解颗粒在通道横截面上的聚焦模式至关重要。在本文中，我们提出了一种解决这个重要问题的方法。为此，首先在矩形横截面通道中分析了惯性微流控技术。结果表明，流体流速和通道的横截面形状对颗粒上的力有很大影响。接下来，利用这些结果通过一些简单的计算提出了一种在非矩形横截面通道中预测平衡位置的方法。该方法基于通过利用不同矩形横截面通道的部分速度分布来近似非矩形横截面通道的速度分布。为了分析该方法的性能，将所提出的方法得到的结果与直接数值模拟（DNS）和七种非矩形通道的实验研究进行了比较。结果表明，该方法能够准确地预测颗粒在通道横截面上的轨迹和平衡位置。
