血清叶酸、25-羟维生素 D3 和钴胺素在 UVB 光疗期间的水平：一项大型前瞻性试验的结果。
Serum levels of folate, 25-hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial.
机构信息
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
出版信息
J Eur Acad Dermatol Venereol. 2020 Feb;34(2):385-391. doi: 10.1111/jdv.15941. Epub 2019 Oct 8.
BACKGROUND
Narrowband UVB phototherapy (NB-UVB) is a mainstay in the treatment of numerous inflammatory dermatoses. Whereas, a wealth of studies has shown that NB-UVB treatment increases 25-hydroxyvitamin D3 (25(OH)D) levels, only sparse and controversial data exist on its effect on serum folate and cobalamin.
OBJECTIVES
To determine whether exposure to NB-UVB alters serum folate or cobalamin levels.
METHODS
A single-centre, prospective, open observational study on 101 patients subjected to NB-UVB phototherapy between late fall and early spring. Serum folate, 25(OH)D and cobalamin levels were measured after 0, 12, 24 and 36 NB-UVB exposures.
RESULTS
After 12 NB-UVB exposures a significant decrease of mean serum folate (-1.0 nmol/L; P = 0.03) and cobalamin (-14.5 pmol/L, P = 0.03) levels was observed whereas serum levels of 25(OH)D showed a significant increase (35.4 nmol/L, P < 0.0001).
CONCLUSIONS
A standard course of NB-UVB induces a small but significant decrease of serum folate and cobalamin levels.
背景
窄谱中波紫外线光疗（NB-UVB）是治疗多种炎症性皮肤病的主要方法。虽然大量研究表明 NB-UVB 治疗可提高 25-羟维生素 D3（25(OH)D）水平，但关于其对血清叶酸和钴胺素的影响仅有少量且存在争议的数据。
目的
确定暴露于 NB-UVB 是否会改变血清叶酸或钴胺素水平。
方法
一项单中心、前瞻性、开放观察性研究，共纳入 101 例在深秋至早春期间接受 NB-UVB 光疗的患者。在 0、12、24 和 36 次 NB-UVB 照射后测量血清叶酸、25(OH)D 和钴胺素水平。
结果
在 12 次 NB-UVB 照射后，平均血清叶酸（-1.0 nmol/L；P = 0.03）和钴胺素（-14.5 pmol/L，P = 0.03）水平显著下降，而 25(OH)D 血清水平显著增加（35.4 nmol/L，P < 0.0001）。
结论
标准疗程的 NB-UVB 会导致血清叶酸和钴胺素水平出现轻微但显著的下降。
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