• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血清叶酸、25-羟维生素 D3 和钴胺素在 UVB 光疗期间的水平：一项大型前瞻性试验的结果。

Serum levels of folate, 25-hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial.

机构信息

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

出版信息

J Eur Acad Dermatol Venereol. 2020 Feb;34(2):385-391. doi: 10.1111/jdv.15941. Epub 2019 Oct 8.

DOI:10.1111/jdv.15941
PMID:31494977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7027503/
Abstract

BACKGROUND

Narrowband UVB phototherapy (NB-UVB) is a mainstay in the treatment of numerous inflammatory dermatoses. Whereas, a wealth of studies has shown that NB-UVB treatment increases 25-hydroxyvitamin D3 (25(OH)D) levels, only sparse and controversial data exist on its effect on serum folate and cobalamin.

OBJECTIVES

To determine whether exposure to NB-UVB alters serum folate or cobalamin levels.

METHODS

A single-centre, prospective, open observational study on 101 patients subjected to NB-UVB phototherapy between late fall and early spring. Serum folate, 25(OH)D and cobalamin levels were measured after 0, 12, 24 and 36 NB-UVB exposures.

RESULTS

After 12 NB-UVB exposures a significant decrease of mean serum folate (-1.0 nmol/L; P = 0.03) and cobalamin (-14.5 pmol/L, P = 0.03) levels was observed whereas serum levels of 25(OH)D showed a significant increase (35.4 nmol/L, P < 0.0001).

CONCLUSIONS

A standard course of NB-UVB induces a small but significant decrease of serum folate and cobalamin levels.

摘要

背景

窄谱中波紫外线光疗（NB-UVB）是治疗多种炎症性皮肤病的主要方法。虽然大量研究表明 NB-UVB 治疗可提高 25-羟维生素 D3（25(OH)D）水平，但关于其对血清叶酸和钴胺素的影响仅有少量且存在争议的数据。

目的

确定暴露于 NB-UVB 是否会改变血清叶酸或钴胺素水平。

方法

一项单中心、前瞻性、开放观察性研究，共纳入 101 例在深秋至早春期间接受 NB-UVB 光疗的患者。在 0、12、24 和 36 次 NB-UVB 照射后测量血清叶酸、25(OH)D 和钴胺素水平。

结果

在 12 次 NB-UVB 照射后，平均血清叶酸（-1.0 nmol/L；P = 0.03）和钴胺素（-14.5 pmol/L，P = 0.03）水平显著下降，而 25(OH)D 血清水平显著增加（35.4 nmol/L，P < 0.0001）。

结论

标准疗程的 NB-UVB 会导致血清叶酸和钴胺素水平出现轻微但显著的下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/6f7d9bad2710/JDV-34-385-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/cca4b6658a34/JDV-34-385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/b693ff32103b/JDV-34-385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/789ebd36e443/JDV-34-385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/6f7d9bad2710/JDV-34-385-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/cca4b6658a34/JDV-34-385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/b693ff32103b/JDV-34-385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/789ebd36e443/JDV-34-385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f993/7027503/6f7d9bad2710/JDV-34-385-g004.jpg

相似文献

1
Serum levels of folate, 25-hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial.血清叶酸、25-羟维生素 D3 和钴胺素在 UVB 光疗期间的水平：一项大型前瞻性试验的结果。
J Eur Acad Dermatol Venereol. 2020 Feb;34(2):385-391. doi: 10.1111/jdv.15941. Epub 2019 Oct 8.
2
Effect of narrowband ultraviolet B phototherapy on serum folic acid levels in patients with psoriasis.窄谱中波紫外线光疗对银屑病患者血清叶酸水平的影响。
Lasers Med Sci. 2011 Jul;26(4):481-5. doi: 10.1007/s10103-011-0895-0. Epub 2011 Feb 23.
3
Serum 25-hydroxyvitamin D increases with NB-UVB and UVA/UVB phototherapy in patients with psoriasis and atopic dermatitis in Western Australia.在西澳大利亚，银屑病和特应性皮炎患者接受窄谱中波紫外线（NB-UVB）及长波紫外线/中波紫外线（UVA/UVB）光疗后，血清25-羟维生素D水平升高。
Australas J Dermatol. 2016 May;57(2):115-21. doi: 10.1111/ajd.12315. Epub 2015 Apr 27.
4
Narrowband ultraviolet B course improves vitamin D balance in women in winter.窄谱中波紫外线疗程可改善冬季女性的维生素 D 平衡。
Br J Dermatol. 2010 Apr;162(4):848-53. doi: 10.1111/j.1365-2133.2010.09629.x. Epub 2010 Jan 22.
5
Influence of narrowband UVB phototherapy on vitamin D and folate status.窄谱中波紫外线光疗对维生素 D 和叶酸状况的影响。
Exp Dermatol. 2010 Aug;19(8):e67-72. doi: 10.1111/j.1600-0625.2009.00987.x.
6
Prospective Investigation of 25(OH)D3 Serum Concentration Following UVB Narrow Band Phototherapy in Patients with Psoriasis and Atopic Dermatitis.银屑病和特应性皮炎患者窄谱中波紫外线光疗后25(OH)D3血清浓度的前瞻性研究
Anticancer Res. 2016 Mar;36(3):1439-44.
7
Narrow-band ultraviolet B exposure increases serum vitamin D levels in haemodialysis patients.窄谱中波紫外线照射可提高血液透析患者的血清维生素D水平。
Nephrol Dial Transplant. 2012 Jun;27(6):2435-40. doi: 10.1093/ndt/gfr700. Epub 2011 Dec 15.
8
Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3.窄谱 UVB、UVA/UVBnb 和 UVA1 光疗对血清 25-羟维生素 D3 的影响不同。
J Am Acad Dermatol. 2013 Oct;69(4):530-6. doi: 10.1016/j.jaad.2013.04.058. Epub 2013 Jul 11.
9
Influence of narrowband ultraviolet B phototherapy on serum folate level in skin of color females: A cross-sectional study.窄谱中波紫外线光疗对有色人种女性皮肤中血清叶酸水平的影响：一项横断面研究。
Int J Womens Dermatol. 2022 Mar 21;8(1):e005. doi: 10.1097/JW9.0000000000000005. eCollection 2022 Mar.
10
Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration.窄谱中波紫外线照射与口服维生素 D 替代对血清 25-羟维生素 D 浓度的比较。
Br J Dermatol. 2012 Jul;167(1):160-4. doi: 10.1111/j.1365-2133.2012.10990.x.

引用本文的文献

1
100 YEARS OF VITAMIN D: Dose-response for change in 25-hydroxyvitamin D after UV exposure: outcome of a systematic review.维生素D的百年历程：紫外线照射后25-羟基维生素D变化的剂量反应：一项系统评价的结果
Endocr Connect. 2021 Oct 15;10(10):R248-R266. doi: 10.1530/EC-21-0308.

本文引用的文献

1
Folate and phototherapy: What should we inform our patients?叶酸与光疗：我们应向患者告知哪些内容？
J Am Acad Dermatol. 2017 Nov;77(5):958-964. doi: 10.1016/j.jaad.2016.10.016.
2
25-Hydroxyvitamin-D3 serum modulation after use of sunbeds compliant with European Union standards: A randomized open observational controlled trial.使用符合欧盟标准的日光浴床后血清 25-羟维生素 D3 的调节：一项随机开放观察性对照试验。
J Am Acad Dermatol. 2017 Jul;77(1):48-54. doi: 10.1016/j.jaad.2017.02.029. Epub 2017 Apr 14.
3
Sun exposure and 25-hydroxyvitamin D levels in a community sample: Quantifying the association with electronic dosimeters.
户外阳光暴露与社区样本中 25-羟维生素 D 水平：电子剂量计定量评估两者关联。
J Expo Sci Environ Epidemiol. 2017 Sep;27(5):471-477. doi: 10.1038/jes.2016.51. Epub 2016 Sep 7.
4
S1-Guidelines on UV phototherapy and photochemotherapy.紫外线光疗和光化学疗法指南。 （S1可能是指南的编号之类，这里按字面意思翻译为“S1 -” ）
J Dtsch Dermatol Ges. 2016 Aug;14(8):853-76. doi: 10.1111/ddg.12912.
5
Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium.蕈样肉芽肿和塞扎里综合征光疗指南：美国皮肤淋巴瘤联合会的共识声明。
J Am Acad Dermatol. 2016 Jan;74(1):27-58. doi: 10.1016/j.jaad.2015.09.033. Epub 2015 Nov 4.
6
Serum levels of homocysteine, folate and vitamin B12 in patients with vitiligo before and after treatment with narrow band ultraviolet B phototherapy and in a group of controls.血清同型半胱氨酸、叶酸和维生素 B12 水平在窄带紫外线 B 光疗前后治疗的白癜风患者和对照组中的变化。
J Photochem Photobiol B. 2015 Jul;148:174-180. doi: 10.1016/j.jphotobiol.2015.04.005. Epub 2015 Apr 17.
7
Influence of multiple UV exposures on serum cobalamin and vitamin D levels in healthy females.多次紫外线照射对健康女性血清钴胺素和维生素D水平的影响。
Scand J Public Health. 2015 May;43(3):324-30. doi: 10.1177/1403494815572206. Epub 2015 Mar 4.
8
Interventions for vitiligo.白癜风的干预措施。
Cochrane Database Syst Rev. 2015 Feb 24;2015(2):CD003263. doi: 10.1002/14651858.CD003263.pub5.
9
The action spectrum for folic acid photodegradation in aqueous solutions.水溶液中叶酸光降解的作用光谱。
J Photochem Photobiol B. 2013 Sep 5;126:11-6. doi: 10.1016/j.jphotobiol.2013.05.011. Epub 2013 Jun 7.
10
The effects of a mid-winter 8-week course of sub-sunburn sunbed exposures on tanning, vitamin D status and colds.冬季 8 周中低水平太阳床暴露对晒黑、维生素 D 状况和感冒的影响。
Photochem Photobiol Sci. 2012 Dec;11(12):1848-54. doi: 10.1039/c2pp25179e.