阿尔茨海默病脑、血和脑脊液中 microRNAs 的差异表达。

Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid.

机构信息

Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK.

Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.

出版信息

Alzheimers Dement. 2019 Nov;15(11):1468-1477. doi: 10.1016/j.jalz.2019.06.4952. Epub 2019 Sep 5.

DOI:10.1016/j.jalz.2019.06.4952

PMID:31495604

Abstract

INTRODUCTION

Several microRNAs (miRNAs) have been implicated in Alzheimer's disease pathogenesis, but the evidence from individual case-control studies remains inconclusive.

METHODS

A systematic literature review was performed, followed by standardized multistage data extraction, quality control, and meta-analyses on eligible data for brain, blood, and cerebrospinal fluid specimens. Results were compared with miRNAs reported in the abstracts of eligible studies or recent qualitative reviews to assess novelty.

RESULTS

Data from 147 independent data sets across 107 publications were quantitatively assessed in 461 meta-analyses. Twenty-five, five, and 32 miRNAs showed studywide significant differential expression (α < 1·08 × 10) in brain, cerebrospinal fluid, and blood-derived specimens, respectively, with 5 miRNAs showing differential expression in both brain and blood. Of these 57 miRNAs, 13 had not been reported in the abstracts of previous original or review articles.

DISCUSSION

Our systematic assessment of differential miRNA expression is the first of its kind in Alzheimer's disease and highlights several miRNAs of potential relevance.

摘要

简介

已有多种 microRNAs（miRNAs）被认为与阿尔茨海默病的发病机制有关，但来自个体病例对照研究的证据仍不明确。

方法

我们进行了系统的文献综述，随后对脑、血和脑脊液标本的合格数据进行了标准化多阶段数据提取、质量控制和荟萃分析。将结果与合格研究的摘要或最近的定性综述中报告的 miRNAs 进行比较，以评估新颖性。

结果

在 107 篇出版物的 147 个独立数据集的数据中，在 461 项荟萃分析中进行了定量评估。分别有 25、5 和 32 个 miRNAs 在脑、脑脊液和血液样本中显示出全研究范围内的差异表达（α<1·08×10），其中 5 个 miRNAs 在脑和血液中均显示出差异表达。在这 57 个 miRNAs 中，有 13 个未在之前的原始或综述文章的摘要中报道过。