Uehara Masaaki, Yamazaki Hiroki, Yoshikawa Noritada, Kuribara-Souta Akiko, Tanaka Hirotoshi
Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Division of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Endocr J. 2020 Jan 28;67(1):21-30. doi: 10.1507/endocrj.EJ19-0205. Epub 2019 Sep 7.
Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing's syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing's syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.
糖皮质激素在包括新陈代谢在内的体内稳态调节中发挥着关键作用。在库欣综合征患者中，长期糖皮质激素过量会破坏生理内环境，导致中心性肥胖、肌肉萎缩、脂肪肝和胰岛素抵抗。然而，糖皮质激素各种代谢效应之间的关系仍不清楚。在本研究中，我们研究了库欣综合征的雄性小鼠模型，并表明糖皮质激素过量会改变代谢表型和身体组成，这可能涉及骨骼肌、肝脏和脂肪组织之间的相互作用。
