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呼出气冷凝液中骨膜蛋白在轻度哮喘儿童中的浓度。

Periostin concentration in exhaled breath condensate in children with mild asthma.

机构信息

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.

Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw, Warsaw, Poland.

出版信息

J Asthma. 2021 Jan;58(1):60-68. doi: 10.1080/02770903.2019.1659312. Epub 2019 Sep 9.

Abstract

OBJECTIVE

Periostin is considered to be a marker of eosinophilic inflammation in patients with asthma. However, there are no literature data on exhaled breath condensate (EBC) periostin level in pediatric patients with asthma. The aim of this study was to analyze EBC periostin concentration in children with mild asthma and to evaluate the potential usefulness of EBC periostin level as a biomarker for the disease.

METHODS

EBC and serum periostin concentrations were measured by enzyme-linked immunosorbent assay in 23 children with asthma and 23 healthy controls.

RESULTS

EBC periostin concentration was 250- to 780-fold lower than that found in serum. No significant differences between serum nor EBC periostin concentration in asthmatics and the control group were showed. The comparison between children with Th2 and non-Th2 type of asthma did not show significant differences in periostin concentration, both in serum and EBC. Serum periostin concentration inversely correlated with BMI and age not only in asthma patients but also in controls.

CONCLUSIONS

In children with mild asthma, periostin may be measured not only in serum but also in EBC. The low periostin level in patients with mild asthma and lack of difference between asthmatic subjects and controls indicate that EBC periostin may not be useful as an asthma biomarker in this group.

摘要

目的

骨膜蛋白被认为是哮喘患者嗜酸粒细胞炎症的标志物。然而,目前尚无关于小儿哮喘患者呼出气冷凝液(EBC)骨膜蛋白水平的文献数据。本研究旨在分析轻度哮喘儿童的 EBC 骨膜蛋白浓度,并评估 EBC 骨膜蛋白水平作为疾病生物标志物的潜在用途。

方法

通过酶联免疫吸附试验测量 23 例哮喘儿童和 23 例健康对照者的 EBC 和血清骨膜蛋白浓度。

结果

EBC 骨膜蛋白浓度比血清中低 250-780 倍。哮喘组和对照组血清和 EBC 骨膜蛋白浓度无显著差异。Th2 型和非 Th2 型哮喘儿童之间的骨膜蛋白浓度比较,无论是在血清还是 EBC 中均无显著差异。血清骨膜蛋白浓度不仅在哮喘患者中,而且在对照组中均与 BMI 和年龄呈负相关。

结论

在轻度哮喘儿童中,骨膜蛋白不仅可以在血清中测量,也可以在 EBC 中测量。轻度哮喘患者骨膜蛋白水平较低,且哮喘患者与对照组之间无差异,表明 EBC 骨膜蛋白在该组患者中可能不适用于作为哮喘生物标志物。

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