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全身性牛磺酸治疗可对视网膜光感受器变性和视觉功能损害起到神经保护作用。

Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments.

作者信息

Tao Ye, He Miao, Yang Qinghua, Ma Zhao, Qu Yingxin, Chen Wen, Peng Guanghua, Teng Dengke

机构信息

Department of Physiology, Basic Medical College, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

Lab of Visual Cell Differentiation, Basic Medical College, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

出版信息

Drug Des Devel Ther. 2019 Aug 7;13:2689-2702. doi: 10.2147/DDDT.S194169. eCollection 2019.

DOI:10.2147/DDDT.S194169
PMID:31496648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6689665/
Abstract

OBJECTIVE

Retinitis pigmentosa causes progressive photoreceptor degeneration in the subjects while no clinical therapy exists. The present study sought to evaluate the potential protective effects of taurine on a pharmacologically induced RP animal model.

METHODS

Photoreceptor degeneration in mice was induced by an intraperitoneal injection of N-methyl-N-nitrosourea (MNU). The MNU-administrated mouse received taurine treatment and then they were examined by electroretinography, spectral-domain optical coherence tomography, optokinetic test, and histological and immunohistochemistry assay.

RESULTS

Prominent taurine deficiency was found in the retinas of MNU-administered mice. Intravenous taurine treatment increased significantly the retinal taurine level. Morphological studies showed that taurine could alleviate the retinal disorganizations in the MNU-induced mice. Taurine also ameliorated the visual impairments in the MNU-induced mice as evidenced by functional examinations. Immunostaining experiments demonstrated that both the M-cone and S-cone populations in the degenerative retinas are rescued by taurine. In particular, the M-cone photoreceptors in superior-temporal quadrant and the S-cone photoreceptors in inferior-nasal quadrant were preferentially rescued. Mechanism study showed that the photoreceptor apoptosis and oxidative stress in the degenerative retina were effectively alleviated by taurine treatment.

CONCLUSION

Taurine is protective against the MNU-induced photoreceptor degeneration. Systemic taurine administration may act as a promising therapeutic potion for retinopathies with chronic cycle.

摘要

目的

视网膜色素变性会导致患者的光感受器进行性退化，而目前尚无临床治疗方法。本研究旨在评估牛磺酸对药物诱导的视网膜色素变性动物模型的潜在保护作用。

方法

通过腹腔注射N-甲基-N-亚硝基脲（MNU）诱导小鼠光感受器退化。对接受MNU处理的小鼠进行牛磺酸治疗，然后通过视网膜电图、光谱域光学相干断层扫描、视动性试验以及组织学和免疫组织化学分析对它们进行检查。

结果

在接受MNU处理的小鼠视网膜中发现明显的牛磺酸缺乏。静脉注射牛磺酸治疗显著提高了视网膜牛磺酸水平。形态学研究表明，牛磺酸可以减轻MNU诱导小鼠的视网膜紊乱。功能检查证明，牛磺酸还改善了MNU诱导小鼠的视觉障碍。免疫染色实验表明，退化视网膜中的M视锥细胞和S视锥细胞群体均被牛磺酸挽救。特别是，颞上象限的M视锥光感受器和鼻下象限的S视锥光感受器得到了优先挽救。机制研究表明，牛磺酸治疗有效减轻了退化视网膜中的光感受器凋亡和氧化应激。

结论

牛磺酸对MNU诱导的光感受器退化具有保护作用。全身给予牛磺酸可能是一种有前景的慢性视网膜病变治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/6beb5e547519/DDDT-13-2689-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/0c981dd22241/DDDT-13-2689-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/ba8065ba66d2/DDDT-13-2689-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/7376f0d61473/DDDT-13-2689-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/0e434490fc2a/DDDT-13-2689-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/f77be99b22b0/DDDT-13-2689-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/8e7ede846fec/DDDT-13-2689-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/b42a6509aab5/DDDT-13-2689-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/6beb5e547519/DDDT-13-2689-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/0c981dd22241/DDDT-13-2689-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/ba8065ba66d2/DDDT-13-2689-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/7376f0d61473/DDDT-13-2689-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/0e434490fc2a/DDDT-13-2689-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/f77be99b22b0/DDDT-13-2689-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/8e7ede846fec/DDDT-13-2689-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/b42a6509aab5/DDDT-13-2689-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/6689665/6beb5e547519/DDDT-13-2689-g0008.jpg

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