Lee Eun Nam, Choe Sun Yi, Choi Eun Hui, Lee Min Ju
College of Nursing, Dong-A University, Busan, Korea.
Department of Obstetrics & Gynecology, Dong-A University Hospital, Busan, Korea.
J Menopausal Med. 2019 Aug;25(2):100-107. doi: 10.6118/jmm.19197. Epub 2019 Aug 29.
To summarize the evidence regarding the association of parity and breast feeding duration with the risk of osteoporosis in postmenopausal Korean women. This was because studies have been inconsistent regarding the effect of parity and breast feeding duration on the risk of osteoporosis.
A systematic literature search of relevant studies published by December 26, 2018 was conducted in PubMed, EMBASE, the Cochrane Library, CINAHL, RISS, KISS, KMbase, and KoreaMed. Outcome estimates of odds ratio (OR) or standardized mean difference were pooled with fixed or random-effect model. In case of heterogeneity, subgroup analysis was conducted.
Seven cross-sectional studies (with 3,813 subjects) were included in the analysis. OR for osteoporosis was 1.43 (95% confidence interval [CI] = 1.09-1.88, = 0.010) in postmenopausal women with higher parity compared to those with less parity. Moreover, OR for osteoporosis was 1.93 (95% CI = 1.28-2.93, = 0.002) in postmenopausal women with longer durations of breast feeding than in those with shorter durations of breast feeding.
This study revealed that duration of breast feeding increased the risk of osteoporosis in postmenopausal Korean women. More cohort studies with high quality research designs are needed to confirm our results.
总结有关生育次数和母乳喂养持续时间与绝经后韩国女性骨质疏松症风险之间关联的证据。这是因为关于生育次数和母乳喂养持续时间对骨质疏松症风险的影响，各项研究结果并不一致。
于2018年12月26日前在PubMed、EMBASE、Cochrane图书馆、CINAHL、RISS、KISS、KMbase和KoreaMed中对相关研究进行系统的文献检索。采用固定效应模型或随机效应模型汇总比值比（OR）或标准化均数差的结果估计值。若存在异质性，则进行亚组分析。
分析纳入了7项横断面研究（共3813名受试者）。与生育次数较少的绝经后女性相比，生育次数较多的绝经后女性患骨质疏松症的OR为1.43（95%置信区间[CI]=1.09 - 1.88，P = 0.010）。此外，母乳喂养持续时间较长的绝经后女性患骨质疏松症的OR为1.93（95%CI = 1.28 - 2.93，P = 0.002），高于母乳喂养持续时间较短的绝经后女性。
本研究表明，母乳喂养持续时间会增加绝经后韩国女性患骨质疏松症的风险。需要更多高质量研究设计的队列研究来证实我们的结果。
