一名16岁患有万古霉素诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征男孩的单倍型分析。

Haplotype analysis in a 16-year-old boy with vancomycin-induced DRESS syndrome.

作者信息

Ercan Nazlı, Yeşillik Sait, Demirel Fevzi, Tırık Nihan, Kartal Özgür

机构信息

Department of Pediatric Health and Diseases, Pediatric Immunology and Allergy, University of Health Sciences, Gulhane Training and Research Hospital, Etlik Ankara, Turkey.

Department of Immunology and Allergy, University of Health Sciences, Gulhane Training and Research Hospital, Etlik Ankara, Turkey.

出版信息

Pediatr Dermatol. 2019 Nov;36(6):992-994. doi: 10.1111/pde.13994. Epub 2019 Sep 9.

DOI:10.1111/pde.13994

PMID:31497897

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but life-threatening multisystem adverse reaction to a medication, with vancomycin being one of the most common cause reported. We present the HLA analysis of a pediatric patient who developed DRESS related to vancomycin and compared the results with the available literature. With further data, the use of pretreatment HLA analysis to prevent vancomycin related DRESS may be a valuable option in the near future.

摘要

药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种罕见但危及生命的药物多系统不良反应，万古霉素是最常报道的病因之一。我们展示了一名发生与万古霉素相关的DRESS的儿科患者的HLA分析，并将结果与现有文献进行比较。随着更多数据的积累，在不久的将来，使用预处理HLA分析来预防万古霉素相关的DRESS可能是一个有价值的选择。