CO 结合力在预测 II 期和 III 期结直肠癌患者预后中的意义。

The significance of CO combining power in predicting prognosis of patients with stage II and III colorectal cancer.

机构信息

Department of Medical Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, No.42, Baiziting, Nanjing 210009, Jiangsu Province, PR China.

Clinic laboratory of Institute of Dermatology & Hospital for Skin Diseases, Chinese Academy of Medical Sciences, No.12, Jiangwangmiao Street, Xuanwu District, Nanjing 210042, Jiangsu Province, PR China.

出版信息

Biomark Med. 2019 Sep;13(13):1071-1080. doi: 10.2217/bmm-2018-0321. Epub 2019 Sep 9.

DOI:10.2217/bmm-2018-0321

PMID:31497992

Abstract

This study was to evaluate whether COCP level in venous blood could predict prognosis of patients with colorectal cancer (CRC). A retrospective cohort of 238 patients with CRC who received surgical resection and 176 CRC Stage IV patients were included. A total of 114 healthy people were recruited as control. COCP levels were obtained from medical records. Survival analysis was performed to evaluate COCP predictive potential. The patients were divided into COCP high or low group based on COCP optimal cut-off values. The decreased COCP in CRC patients was associated with advanced clinical stage, and suggested that decreased COCP may predict the worse outcomes of disease-free survival in II/III stage CRC patients.

摘要

本研究旨在评估静脉血中 COCP 水平是否可预测结直肠癌（CRC）患者的预后。纳入了 238 例接受手术切除的 CRC 患者和 176 例 CRC Ⅳ期患者进行回顾性队列研究。共招募了 114 名健康人作为对照。COCP 水平从病历中获得。采用生存分析评估 COCP 的预测潜力。根据 COCP 的最佳截断值将患者分为 COCP 高或低组。CRC 患者 COCP 的降低与临床分期较晚有关，提示 COCP 降低可能预示着 II/III 期 CRC 患者无病生存结局更差。