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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tephly T, Green M, Puig J, Irshaid Y

Department of Pharmacology, University of Iowa, Iowa City 52242.

Xenobiotica. 1988 Nov;18(11):1201-10. doi: 10.3109/00498258809042244.

Multiple forms of UDP-glucuronosyltransferase (UDPGTs) have been demonstrated in the livers of all mammalian species that have been studied. Rat liver possesses at least eight different isozymes and human liver has at least five different forms which have been identified. 2. Endogenous substrates (e.g., steroids) are helpful in distinguishing UDPGTs as they generally react with only a single form, whereas xenobiotic substrates (e.g., 4-methyl-umbelliferone, p-nitrophenol) react with several forms of the enzyme. 3. Human liver UDPGTs differ in physical properties and substrate specificity from these enzymes obtained from laboratory animals. Hence, it is necessary to study human liver UDPGTs to elucidate substrate specificity and to understand drug-endogenous substrate interaction in humans.

在所有已研究的哺乳动物物种的肝脏中都已证实存在多种形式的尿苷二磷酸葡萄糖醛酸基转移酶（UDPGTs）。大鼠肝脏至少拥有八种不同的同工酶，而人类肝脏已鉴定出至少五种不同的形式。2. 内源性底物（如类固醇）有助于区分UDPGTs，因为它们通常仅与单一形式反应，而异源生物底物（如4-甲基伞形酮、对硝基苯酚）则与多种形式的该酶反应。3. 人类肝脏UDPGTs在物理性质和底物特异性方面与从实验动物获得的这些酶不同。因此，有必要研究人类肝脏UDPGTs以阐明底物特异性并了解人类体内药物与内源性底物的相互作用。

Tephly T, Green M, Puig J, Irshaid Y

Department of Pharmacology, University of Iowa, Iowa City 52242.

Xenobiotica. 1988 Nov;18(11):1201-10. doi: 10.3109/00498258809042244.

Multiple forms of UDP-glucuronosyltransferase (UDPGTs) have been demonstrated in the livers of all mammalian species that have been studied. Rat liver possesses at least eight different isozymes and human liver has at least five different forms which have been identified. 2. Endogenous substrates (e.g., steroids) are helpful in distinguishing UDPGTs as they generally react with only a single form, whereas xenobiotic substrates (e.g., 4-methyl-umbelliferone, p-nitrophenol) react with several forms of the enzyme. 3. Human liver UDPGTs differ in physical properties and substrate specificity from these enzymes obtained from laboratory animals. Hence, it is necessary to study human liver UDPGTs to elucidate substrate specificity and to understand drug-endogenous substrate interaction in humans.

在所有已研究的哺乳动物物种的肝脏中都已证实存在多种形式的尿苷二磷酸葡萄糖醛酸基转移酶（UDPGTs）。大鼠肝脏至少拥有八种不同的同工酶，而人类肝脏已鉴定出至少五种不同的形式。2. 内源性底物（如类固醇）有助于区分UDPGTs，因为它们通常仅与单一形式反应，而异源生物底物（如4-甲基伞形酮、对硝基苯酚）则与多种形式的该酶反应。3. 人类肝脏UDPGTs在物理性质和底物特异性方面与从实验动物获得的这些酶不同。因此，有必要研究人类肝脏UDPGTs以阐明底物特异性并了解人类体内药物与内源性底物的相互作用。