Odonkor Charles A, Orman Sebastian, Orhurhu Vwaire, Stone Martha E, Ahmed Shihab
Division of Pain, Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
Department of Orthopaedics, Georgetown University School of Medicine, Washington, DC.
Pain Med. 2019 Dec 1;20(12):2479-2494. doi: 10.1093/pm/pnz185.
The purpose of this review is to critically appraise the literature for evidence supporting the health care resource utilization and cost-effectiveness of spinal cord stimulation (SCS) compared with conventional therapies (CTs) for chronic low back and leg pain.
The PubMed, MEDLINE, Embase, CINAHL, and Rehabilitation & Sports Medicine databases were searched for studies published from January 2008 through October 2018, using the following MeSH terms: "spinal cord stimulation," "chronic pain," "back pain," "patient readmission," "economics," and "costs and cost analysis." Additional sources were added based on bibliographies and consultation with experts. The following data were extracted and analyzed: demographic information, study design, objectives, sample sizes, outcome measures, SCS indications, complications, costs, readmissions, and resource utilization data.
Of 204 studies screened, 11 studies met inclusion criteria, representing 31,439 SCS patients and 299,182 CT patients. The mean age was 53.5 years for SCS and 55.6 years for CT. In eight of 11 studies, SCS was associated with favorable outcomes and found to be more cost-effective than CT for chronic low back pain. Compared with CT, SCS resulted in shorter hospital stays and lower complication rates and health care costs at 90 days. SCS was associated with significant improvement in health-related quality of life, health status, and quality-adjusted life-years.
For the treatment of chronic low back and leg pain, the majority of studies are of fair quality, with level 3 or 4 evidence in support of SCS as potentially more cost-effective than CT, with less resource expenditure but higher complication rates. SCS therapy may yet play a role in mitigating the financial burden associated with chronic low back and leg pain.
本综述旨在严格评估文献,以寻找证据支持脊髓刺激(SCS)与传统疗法(CT)相比,在治疗慢性腰腿痛方面的医疗资源利用情况和成本效益。
检索了PubMed、MEDLINE、Embase、CINAHL以及康复与运动医学数据库,查找2008年1月至2018年10月发表的研究,使用了以下医学主题词:“脊髓刺激”、“慢性疼痛”、“背痛”、“患者再入院”、“经济学”以及“成本与成本分析”。根据参考文献和专家咨询补充了其他来源。提取并分析了以下数据:人口统计学信息、研究设计、目的、样本量、结局指标、SCS适应症、并发症、成本、再入院情况以及资源利用数据。
在筛选的204项研究中,11项研究符合纳入标准,代表了31439例SCS患者和299182例CT患者。SCS组的平均年龄为53.5岁,CT组为55.6岁。在11项研究中的8项中,SCS与良好结局相关,并且发现对于慢性腰痛,SCS比CT更具成本效益。与CT相比,SCS导致住院时间更短,90天时并发症发生率和医疗成本更低。SCS与健康相关生活质量、健康状况和质量调整生命年的显著改善相关。
对于慢性腰腿痛的治疗,大多数研究质量一般,有3级或4级证据支持SCS可能比CT更具成本效益,资源支出更少但并发症发生率更高。SCS疗法可能在减轻与慢性腰腿痛相关的经济负担方面发挥作用。