Kohli Y, Katoh T, Suzuki K
Second Department of Internal Medicine, Fukui Medical School, Japan.
Drugs Exp Clin Res. 1988;14(11):673-8.
A newly developed prostaglandin E2 derivative, enprostil (TA/RS-84135), was administered to five healthy volunteers in the stomach and duodenum through a teflon tube to examine its effect on amogastrin-stimulated gastric acid secretion. The acid output 1-3 h after administration of enprostil (35 micrograms) decreased remarkably as compared with that in the same period after placebo administration. However, no significant difference in antisecretory effect was observed between the two routes of administration. A decrease in pepsin output occurred in parallel with the decrease in acid output. These results suggest that the antisecretory effect of enprostil is at least partially due to systemic absorption and the predominantly topical action seen in animals does not seem to occur in man. No side-effects attributable to enprostil were observed during the test period. In conclusion, enprostil seems to be clinically useful as an antiulcer agent.
一种新研制的前列腺素E2衍生物恩前列素（TA/RS - 84135），通过聚四氟乙烯管经胃和十二指肠给予5名健康志愿者，以研究其对胃泌素刺激的胃酸分泌的影响。给予恩前列素（35微克）后1 - 3小时的胃酸分泌量与给予安慰剂后同期相比显著下降。然而，两种给药途径的抗分泌作用未观察到显著差异。胃蛋白酶分泌量的减少与胃酸分泌量的减少同时发生。这些结果表明，恩前列素的抗分泌作用至少部分归因于全身吸收，在动物中所见的主要局部作用在人类中似乎并不发生。在试验期间未观察到归因于恩前列素的副作用。总之，恩前列素似乎作为一种抗溃疡药物在临床上是有用的。
