Département de Microbiologie et Médecine Moléculaire, Centre Médical Universitaire, Université de Genève, 1211 Geneva 4, Switzerland; email:
Annu Rev Microbiol. 2019 Sep 8;73:579-599. doi: 10.1146/annurev-micro-020518-120235.
The Apicomplexa phylum includes a large group of obligate intracellular protozoan parasites responsible for important diseases in humans and animals. is a widespread parasite with considerable versatility, and it is capable of infecting virtually any warm-blooded animal, including humans. This outstanding success can be attributed at least in part to an efficient and continuous sensing of the environment, with a ready-to-adapt strategy. This review updates the current understanding of the signals governing the lytic cycle of , with particular focus on egress from infected cells, a key step for balancing survival, multiplication, and spreading in the host. We cover the recent advances in the conceptual framework of regulation of microneme exocytosis that ensures egress, motility, and invasion. Particular emphasis is given to the trigger molecules and signaling cascades regulating exit from host cells.
顶复门（Apicomplexa）包括一大组专性细胞内原生动物寄生虫，它们是人类和动物重要疾病的病原体。疟原虫是一种广泛存在的寄生虫，具有相当大的多功能性，能够感染几乎所有温血动物，包括人类。这种卓越的成功至少部分归因于对环境的高效和持续感知，以及随时准备适应的策略。本综述更新了目前对疟原虫裂解周期调控信号的理解，特别关注从感染细胞中逸出，这是宿主中平衡生存、增殖和传播的关键步骤。我们涵盖了微线体胞吐调节的概念框架的最新进展，该框架确保了逸出、运动和入侵。特别强调了调节宿主细胞外逃的触发分子和信号级联。
