Division of Nephrology and
Department of Physical Therapy, Indiana University School of Health and Human Sciences, Indianapolis, Indiana; and.
J Am Soc Nephrol. 2019 Oct;30(10):1898-1909. doi: 10.1681/ASN.2019040349. Epub 2019 Sep 9.
Reduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality.
We tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/+ ) and normal littermates (NL) were given access to a voluntary running wheel or standard cage conditions for 10 weeks starting at 25 weeks of age when the rats with kidney disease had reached stage 2-3 of CKD. We then measured the effects of wheel running on serum biochemistry, tissue weight, voluntary grip strength, maximal aerobic capacity (VO), body composition and bone micro-CT and mechanics.
Wheel running improved serum biochemistry with decreased creatinine, phosphorous, and parathyroid hormone in the rats with CKD. It improved muscle strength, increased time-to-fatigue (for VO), reduced cortical porosity and improved bone microarchitecture. The CKD rats with voluntary wheel access also had reduced kidney cystic weight and reduced left ventricular mass index.
Voluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.
慢性肾脏病患者的骨骼和肌肉健康状况下降，导致其发病率和死亡率较高。
我们检验了这样一个假设，即自愿轮式跑步会改善 CKD 大鼠模型的肌肉骨骼健康。从 25 周龄开始，患有自发性进行性囊性肾病（Cy/+）的大鼠和正常同窝仔鼠（NL）被给予自愿轮式跑步或标准笼状条件 10 周，此时患有肾病的大鼠已经达到 CKD 2-3 期。然后，我们测量了轮式跑步对血清生化、组织重量、自愿握力、最大有氧能力（VO）、身体成分和骨微 CT 及力学的影响。
轮式跑步改善了血清生化，降低了 CKD 大鼠的肌酐、磷和甲状旁腺激素水平。它还改善了肌肉力量，增加了疲劳时间（用于 VO），减少了皮质骨孔隙率，改善了骨微观结构。有自愿轮式跑步机会的 CKD 大鼠的肾脏囊肿重量也减少了，左心室质量指数也降低了。
自愿轮式跑步对 CKD 大鼠产生了多种有益的全身影响，并改善了它们的身体功能。有必要对 CKD 患者的运动干预进行研究。
