神经营养因子BDNF和GDNF在神经系统对缺血因素影响的适应中的作用。
Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors.
作者信息
Mitroshina E V, Mishchenko T A, Shishkina T V, Vedunova M V
机构信息
N. I. Lobachevsky Nizhny Novgorod National Research State University, Nizhny Novgorod, Russia.
出版信息
Bull Exp Biol Med. 2019 Aug;167(4):574-579. doi: 10.1007/s10517-019-04574-1. Epub 2019 Sep 9.
We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.
我们构建了一个复杂的体外缺血损伤模型。在模拟各种应激因素后，对原代培养物中海马细胞活力的分析揭示了缺血主要病理因素的作用特点。在模拟复杂缺血损伤及其各个病理生理成分的过程中，神经营养因子BDNF和GDNF产生了显著的神经保护作用。神经营养因子GDNF产生的保护作用最为显著。
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