Venkataraman Rajesh, Rashid Muhammed, Shashikantha Bhat, Soumya Ayyappankalathil, Vijayan Greeshma, Manuel Gloriya Grifth, Islam Shahinur
Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri Hospital and Research Center, Adichunchanagiri University, Nagamangala, Karnataka 571448, India.
Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri Hospital and Research Center, Adichunchanagiri University, BG Nagara,Nagamangala, Karnataka 571448, India, Mobile: +91-9886880633.
J Basic Clin Physiol Pharmacol. 2019 Sep 10;31(1):jbcpp-2019-0133. doi: 10.1515/jbcpp-2019-0133.
Background Antihypertensive medications are one among the most highly used drugs across the globe as well as in India, and their prescribing pattern will be erratic despite the various clinical guidelines. Few studies address the pattern and adherence to the standard treatment guidelines in India. This study aimed to review the prescribing pattern of antihypertensive medications in a rural tertiary care teaching Indian hospital and to investigate the adherence to the Joint National Commission-8 (JNC-8) guidelines on prevention, detection, evaluation, and treatment of hypertension in adults. Methods A prospective observational study was conducted among the participants from four different inpatient wards who are aged >18 years, without gender restriction. The prescription pattern was reviewed and adherence to the JNC-8 guidelines was also assessed. A purposive sampling technique was adopted and descriptive statistics were used in Statistical Package for the Social Sciences v16. Results Of the 101 participants included in the study, 62 (61.39%) were female, 23.76% were aged <30 and >60 years, and the other 52.48% belong to the range of 30-60 years. As per JNC-8 guidelines, 4.95%, 17.82%, 44.55%, and 32.67% of patients were classified as normal, pre-hypertensive, stage I, and stage II, respectively. Most of them (31.68%) were free from comorbidities. The most (23.76%) prescribed drug was calcium channel blocker (CCB), and 15.84% of the patients received combination therapy. Treatment was effective in 70.30% of the patients through analyzing their blood pressure even though the adherence to the JNC-8 guidelines was only in 54.46%. Conclusions Our study revealed that CCB was the most prescribed drug, and in spite of the only 50% adherence rate, treatment was effective in the majority of the population. The treatment outcome can be improved if the adherence rate is increased further.
抗高血压药物是全球以及印度使用最为广泛的药物之一，尽管有各种临床指南，但其处方模式仍不稳定。很少有研究探讨印度的处方模式以及对标准治疗指南的遵循情况。本研究旨在回顾一家印度农村三级护理教学医院抗高血压药物的处方模式，并调查对美国国家联合委员会第8版（JNC - 8）成人高血压预防、检测、评估和治疗指南的遵循情况。方法：对来自四个不同住院病房、年龄大于18岁且无性别限制的参与者进行前瞻性观察研究。回顾处方模式并评估对JNC - 8指南的遵循情况。采用目的抽样技术，并在社会科学统计软件包v16中使用描述性统计方法。结果：纳入研究的101名参与者中，62名（61.39%）为女性，23.76%年龄小于30岁且大于60岁，另外52.48%年龄在30 - 60岁之间。根据JNC - 8指南，分别有4.95%、17.82%、44.55%和32.67%的患者被分类为正常、高血压前期、I期和II期。他们中的大多数（31.68%）没有合并症。最常（23.76%）处方的药物是钙通道阻滞剂（CCB），15.84%的患者接受联合治疗。通过分析患者血压，70.30% 的患者治疗有效，尽管对JNC - 8指南的遵循率仅为54.46%。结论：我们的研究表明CCB是最常处方的药物，尽管遵循率仅为50%，但大多数患者治疗有效。如果进一步提高遵循率，治疗效果可以得到改善。
