Cafaro Giacomo, Bartoloni Elena, Alunno Alessia, Bistoni Onelia, Cipriani Sabrina, Topini Fabiana, Gerli Roberto
Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy.
Isr Med Assoc J. 2019 Jul;21(7):454-459.
Platelets have the ability to influence the immune system and the inflammatory process and may be strongly involved in the whole pathogenic process of chronic inflammatory joint diseases, such as rheumatoid arthritis. They may play a significant role even before the clinical onset of the disease, contributing to the loss of tolerance of the immune system and the induction of autoimmunity. Subsequently, they can interact with the most important cellular players involved in autoimmunity and inflammation, namely innate immunity cells and T cells and eventually contribute to the building of inflammation in the synovium, thus inducing the activation, migration, and proliferation of fibroblasts that eventually lead to joint damage. Due to their peculiar features, studying the behavior of platelets is a challenging task; however, platelets may prove to be valuable therapeutic targets in the future.
血小板具有影响免疫系统和炎症过程的能力，可能在慢性炎症性关节疾病（如类风湿性关节炎）的整个致病过程中发挥重要作用。它们甚至可能在疾病临床发作之前就发挥重要作用，导致免疫系统耐受性丧失和自身免疫的诱导。随后，它们可以与参与自身免疫和炎症的最重要细胞成分，即先天免疫细胞和T细胞相互作用，并最终促进滑膜炎症的形成，从而诱导成纤维细胞的活化、迁移和增殖，最终导致关节损伤。由于其独特的特性，研究血小板的行为是一项具有挑战性的任务；然而，血小板可能在未来被证明是有价值的治疗靶点。
