Centre of Postgraduate Medical Education, Department of Orthopaedics and Trauma Surgery, Professor A. Gruca Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland.
Cells. 2022 Mar 23;11(7):1080. doi: 10.3390/cells11071080.
Platelets are an essential component of hemostasis, with an increasing role in host inflammatory processes in injured tissues. The reaction between receptors and vascular endothelial cells results in the recruitment of platelets in the immune response pathway. The aim of the present review is to describe the role of platelets in osteoarthritis. Platelets induce secretion of biological substances, many of which are key players in the inflammatory response in osteoarthritis. Molecules involved in cartilage degeneration, or being markers of inflammation in osteoarthritis, are cytokines, such as tumor necrosis factor α (TNFα), interleukins (IL), type II collagen, aggrecan, and metalloproteinases. Surprisingly, platelets may also be used as a treatment modality for osteoarthritis. Multiple randomized controlled trials included in our systematic review and meta-analyses prove the effectiveness of platelet-rich plasma (PRP) as a minimally invasive method of pain alleviation in osteoarthritis treatment.
血小板是止血的重要组成部分，在受伤组织的宿主炎症过程中发挥着越来越重要的作用。受体与血管内皮细胞之间的反应导致血小板在免疫反应途径中的募集。本综述的目的是描述血小板在骨关节炎中的作用。血小板诱导生物物质的分泌，其中许多物质是骨关节炎炎症反应中的关键因素。参与软骨退化或作为骨关节炎炎症标志物的分子是细胞因子，如肿瘤坏死因子 α（TNFα）、白细胞介素（IL）、II 型胶原、聚集蛋白聚糖和金属蛋白酶。令人惊讶的是，血小板也可以用作骨关节炎的治疗方法。我们的系统评价和荟萃分析中包含的多项随机对照试验证明了富含血小板的血浆（PRP）作为一种减轻骨关节炎疼痛的微创方法的有效性。
