甲状腺激素受体对整合素αvβ3的发现的临床意义及影响——综述
Clinical Implications and Impact of Discovery of the Thyroid Hormone Receptor on Integrin αvβ3-A Review.
作者信息
Hercbergs Aleck
机构信息
Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, United States.
出版信息
Front Endocrinol (Lausanne). 2019 Aug 23;10:565. doi: 10.3389/fendo.2019.00565. eCollection 2019.
Abstract
Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3'-triiodo-L-thyronine (T3) has enabled clinical implementation whereby exogenous T3 may replace exogenous (or endogenous) T4 to maintain clinical euthyroid hypothyroxinemia that results in significantly better survival in advanced cancer patients without the morbidity of clinical hypothyroidism.
摘要
据报道，甲状腺功能减退症可提高癌症患者的生存率，但直到最近，其假定机制才被确定为整合素αvβ3上的甲状腺素和三碘甲状腺原氨酸受体。认识到促癌性L-甲状腺素（T4）与促代谢性3,5,3'-三碘-L-甲状腺原氨酸（T3）作用的差异，使得临床应用成为可能，即外源性T3可替代外源性（或内源性）T4，以维持临床甲状腺功能正常的低甲状腺素血症，从而在晚期癌症患者中显著提高生存率，且无临床甲状腺功能减退症的发病风险。
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