Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan.
Academic-Industrial Graduate School, Mie University, Tsu, Mie 514-8507, Japan.
Nutrients. 2019 Sep 10;11(9):2170. doi: 10.3390/nu11092170.
Partially hydrolyzed guar gum (PHGG) is a water-soluble dietary fiber and is used in solid and liquid food to regulate gut function. The aim of this study was to investigate effects of PHGG on bowel movements (stool form and frequency), plasma bile acids, quality of life, and gut microbiota of healthy volunteers with a tendency toward diarrhea, i.e., irritable bowel syndrome diarrhea (IBS-D)-like symptoms. A randomized, double-blind, placebo-controlled, and parallel trial was performed on 44 healthy volunteers (22 males, 22 females, 41.9 ± 6.3 years old (average ± SD)) with minimum 7 bowel movements every week, wherein above 50% of their stool was between the Bristol stool scale (BSS) value of 5 and 6. Intake of the PHGG for 3 months significantly improved stool form, evaluated using BSS, and had no effects on stool frequency. BSS was significantly normalized in the group consuming the PHGG compared with the placebo. Comprehensive fecal microbiome analysis by the 16S rRNA-sequence method detected significant changes in the ratio of some bacteria, such as an increase of ( < 0.05) in the PHGG group. Our results suggest that intake of PHGG improves human stool form via regulating intestinal microbiota.
部分水解瓜尔胶（PHGG）是一种水溶性膳食纤维，用于固体和液体食品中以调节肠道功能。本研究旨在研究 PHGG 对易腹泻的健康志愿者（即肠易激综合征腹泻（IBS-D）样症状）的排便情况（粪便形态和频率）、血浆胆汁酸、生活质量和肠道微生物群的影响。在 44 名健康志愿者（22 名男性，22 名女性，41.9 ± 6.3 岁（平均 ± SD））中进行了一项随机、双盲、安慰剂对照和平行试验，这些志愿者每周至少有 7 次排便，其中至少 50%的粪便处于布里斯托粪便量表（BSS）值 5 和 6 之间。摄入 PHGG 3 个月可显著改善粪便形态，BSS 评估结果显示，粪便频率无变化。与安慰剂组相比，PHGG 组的 BSS 明显正常化。通过 16S rRNA 测序方法进行的综合粪便微生物组分析检测到一些细菌比例的显著变化，例如 PHGG 组中（<0.05）的增加。我们的研究结果表明，PHGG 的摄入通过调节肠道微生物群来改善人类的粪便形态。
