Miura Hiroto, Oda Machi, Abe Kanako, Ikeda Hiromi, Fujibayashi Mami, Oda Naoko, Segawa Tomohiro, Abe Aya, Ueta Natsumi, Tsukahara Takamitsu, Takagi Tomohisa, Naito Yuji, Inoue Ryo
Laboratory of Animal Science, Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University, Osaka 573-0101, Japan.
Department of Food Science and Human Nutrition, Faculty of Agriculture, Setsunan University, Osaka 573-0101, Japan.
Microorganisms. 2025 Jul 2;13(7):1561. doi: 10.3390/microorganisms13071561.
Our previous study reported that male university rugby players tended to have a gut with a dysbiotic environment, characterized by abundant pathobiont bacteria and an accumulation of succinate, when compared with age-matched, non-rugby playing healthy males. In the present study, we conducted a randomized, double-blinded, placebo-controlled experiment to evaluate the potential of blackcurrant extract and/or partially hydrolyzed guar gum (PHGG) to improve the gut environment of university rugby players. Participants were supplemented with blackcurrant extract and/or PHGG or a placebo for 4 weeks. Beneficial gut bacteria such as spp. tended to increase ( < 0.10) and spp. increased ( < 0.05) with the intake of blackcurrant extract and/or PHGG. A subgroup analysis further indicated that, unlike in those with a eubiotic gut environment, the dietary supplements also increased the number of beneficial gut bacteria such as spp. ( < 0.10) and spp. ( < 0.10) and fecal SCFA concentrations ( < 0.05) in participants with a possible dysbiotic gut environment. However, a synergistic effect between blackcurrant extract and PHGG was not clearly observed. Although further investigation is recommended, it was concluded that blackcurrant extract and PHGG can at least be used as functional materials to improve gut dysbiosis in university rugby players.
我们之前的研究报告称，与年龄匹配的、不参加橄榄球运动的健康男性相比，男性大学橄榄球运动员的肠道往往具有生态失调的环境，其特征是致病共生菌丰富且琥珀酸积累。在本研究中，我们进行了一项随机、双盲、安慰剂对照实验，以评估黑加仑提取物和/或部分水解瓜尔胶（PHGG）改善大学橄榄球运动员肠道环境的潜力。参与者补充黑加仑提取物和/或PHGG或安慰剂，为期4周。摄入黑加仑提取物和/或PHGG后，有益肠道细菌如 菌属有增加趋势（<0.10）， 菌属增加（<0.05）。亚组分析进一步表明，与肠道生态正常的参与者不同，膳食补充剂还增加了可能存在肠道生态失调环境的参与者中有益肠道细菌如 菌属（<0.10）和 菌属（<0.10）的数量以及粪便短链脂肪酸浓度（<0.05）。然而，未清楚观察到黑加仑提取物和PHGG之间的协同作用。尽管建议进一步研究，但得出的结论是，黑加仑提取物和PHGG至少可作为改善大学橄榄球运动员肠道生态失调的功能材料。
