Heart and Vascular Theme, Karolinska University Hospital and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
Curr Cardiol Rep. 2019 Sep 13;21(10):129. doi: 10.1007/s11886-019-1205-x.
The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques.
Up to a quarter of symptomatic adult valvular disease is caused by multiple left-sided valvular lesions. The etiologic spectrum of this combined disease has shifted from rheumatic to degenerative. Both presentation and diagnosis of lesions are modified compared with isolated disease. Based upon narrative review, there are only limited observational experiences, insufficient to provide robust guidance. These data, however, indicate the feasibility of interventions such as transcatheter aortic valve replacement and edge-to-edge mitral valve repair to treat such disease and mitigate the risks of open surgery. Combined aortic and mitral valve disease is commonly encountered. There is a role for transcatheter interventions based on limited data; however, more research is needed.
评估发表的数据,了解症状性二尖瓣和主动脉瓣联合瓣膜病的发病率、诊断和治疗。此外,确定使用当代经导管技术治疗的作用。
多达四分之一的有症状成人瓣膜病是由多种左侧瓣膜病变引起的。这种联合疾病的病因谱已从风湿性转变为退行性。与孤立性疾病相比,病变的表现和诊断均发生了改变。基于叙述性综述,仅有有限的观察经验,不足以提供有力的指导。然而,这些数据表明经导管主动脉瓣置换术和瓣环成形术等干预措施治疗此类疾病并降低开胸手术风险是可行的。联合主动脉瓣和二尖瓣疾病很常见。根据有限的数据,经导管介入治疗有一定作用;然而,需要更多的研究。