Suljevic Damir, Corbic Anida, Islamagic Erna, Focak Muhamed, Filipic Filip, Alijagic Andi
Department of Biology, Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35, 71000, Sarajevo, Bosnia and Herzegovina.
Environ Toxicol Pharmacol. 2019 Nov;72:103250. doi: 10.1016/j.etap.2019.103250. Epub 2019 Sep 4.
Cadmium is a heavy metal classified as an environmental hazard, and its toxicity is subject to extensive research. Japanese quails were exposed to cadmium chloride (CdCl) ad libitum for 20 days. Bone marrow, peripheral blood and liver were analyzed following the exposure. Moreover, we have provided the very first explanation of hematopoietic lines in Japanese quail. Following CdCl exposure, changes in the number, size and morphology of blood cells were observed in both peripheral blood and bone marrow. Alterations included severe erythrocyte damage, monocytosis and lymphopenia. In the liver of Cd-exposed animals we observed necrotic cells, absence of hematopoietic regions and cytogenetic changes of hepatocytes. Alterations in the bone marrow were also noted, as well as giant phagocytic cells, most likely macrophages. In vivo, CdCl exposure caused swift and destructive changes in the hematopoietic niche, liver and other tissues responsible for the detoxification cycle of cadmium and its compounds.
镉是一种被归类为环境危害物的重金属，其毒性受到广泛研究。日本鹌鹑被随意喂食氯化镉（CdCl）20天。暴露后对骨髓、外周血和肝脏进行了分析。此外，我们首次对日本鹌鹑的造血谱系作出了解释。暴露于氯化镉后，在外周血和骨髓中均观察到血细胞数量、大小和形态的变化。改变包括严重的红细胞损伤、单核细胞增多症和淋巴细胞减少症。在暴露于镉的动物肝脏中，我们观察到坏死细胞、造血区域缺失以及肝细胞的细胞遗传学变化。骨髓中也有改变，还有巨型吞噬细胞，很可能是巨噬细胞。在体内，氯化镉暴露对造血微环境、肝脏以及负责镉及其化合物解毒循环的其他组织造成了迅速且具有破坏性的变化。
