Departamento de Bioquímica da Universidade Federal de São Paulo, Rua Três de Maio, 100, P.O. Box 04044-020, Brazil.
Departamento de Ortodontia da Universidade Guarulhos, Praça Tereza Cristina, 229, Guarulhos, SP, P.O. Box 07023-070 Brazil.
Carbohydr Polym. 2019 Dec 1;225:115199. doi: 10.1016/j.carbpol.2019.115199. Epub 2019 Aug 14.
Proteoglycans (PGs) are proteins which are vital components located in the extracellular matrix, cell surface or intracellular granules. They are linked to polysaccharides called glycosaminoglycans. There are several aspects associated with PGs, such as cell signaling and organization of the extracellular matrix (ECM), making them pivotal participants in many tissue compositions. In teeth, PGs also play an essential role, as many of its components have elaborate ECM structures. However, lack of information on how PGs constitute the various tissues of the tooth and on their roles makes it difficult to elicit the major importance associated with this class of proteins. This review seeks to detail how proteoglycans are involved in many aspects of tooth organization and development, and as far as we are concerned, this has not been performed yet. We have also exemplified the participation of small leucine-rich proteoglycans, a special class of PGs seen in dental trauma cases.
蛋白聚糖（PGs）是一种重要的蛋白质，位于细胞外基质、细胞表面或细胞内颗粒中。它们与称为糖胺聚糖的多糖相连。PGs 与几个方面有关，如细胞信号传导和细胞外基质（ECM）的组织，使它们成为许多组织成分的关键参与者。在牙齿中，PGs 也起着至关重要的作用，因为其许多成分都有精细的 ECM 结构。然而，由于缺乏关于 PGs 如何构成牙齿的各种组织以及它们的作用的信息，因此很难确定与这类蛋白质相关的主要重要性。本综述旨在详细说明蛋白聚糖如何参与牙齿组织和发育的许多方面，据我们所知，这方面尚未有研究。我们还举例说明了小富含亮氨酸的蛋白聚糖（一种在牙外伤病例中发现的特殊 PG 类）的参与。
