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低分子肝素序贯利伐沙班治疗多次内镜下食管胃静脉曲张治疗后合并急性闭塞性门脉肠系膜静脉血栓形成的肝硬化患者

Low-molecular-weight heparin followed by rivaroxaban for acute occlusive portomesenteric vein thrombosis in a cirrhotic patient treated with multiple endoscopic variceal procedures.

机构信息

Department of Gastroenterology, General Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area), Shenyang, PR China; Postgraduate College, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

Department of Gastroenterology, General Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area), Shenyang, PR China.

出版信息

Ann Hepatol. 2020 Sep-Oct;19(5):573-577. doi: 10.1016/j.aohep.2019.08.002. Epub 2019 Sep 5.

DOI:10.1016/j.aohep.2019.08.002
PMID:31521463
Abstract

Acute portomesenteric vein thrombosis is potentially lethal. In the present paper, a cirrhotic patient with a previous history of esophageal variceal bleeding presented with acute occlusive portomesenteric vein thrombosis, but achieved complete recanalization by low-molecular-weight heparin followed by rivaroxaban. Notably, no bleeding episode occurred during anticoagulation therapy. This case supported early initiation of anticoagulation in such patients.

摘要

急性门静脉肠系膜静脉血栓形成可能是致命的。本文报道了一位肝硬化合并食管静脉曲张出血病史的患者,发生急性闭塞性门静脉肠系膜静脉血栓形成,但通过低分子肝素联合利伐沙班治疗后完全再通。值得注意的是,抗凝治疗期间未发生出血事件。该病例支持对这类患者早期进行抗凝治疗。

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引用本文的文献

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Eur J Clin Pharmacol. 2024 Jun;80(6):797-812. doi: 10.1007/s00228-024-03648-y. Epub 2024 Mar 2.
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Association of endoscopic variceal treatment with portal venous system thrombosis in liver cirrhosis: a case-control study.肝硬化患者内镜下静脉曲张治疗与门静脉系统血栓形成的相关性:一项病例对照研究。
Therap Adv Gastroenterol. 2022 May 11;15:17562848221087536. doi: 10.1177/17562848221087536. eCollection 2022.
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Usage of Direct Acting Oral Anticoagulants in Cirrhotic and Non-Cirrhotic Portal Vein Thrombosis: A Systematic Review.
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