Department of Physiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Crete, Herakleion, Crete, Greece.
Hormones (Athens). 2019 Dec;18(4):523-534. doi: 10.1007/s42000-019-00128-2. Epub 2019 Sep 14.
There is emerging evidence that cognitive impairment could be a diabetes mellitus-related complication. It has been suggested that diabetic people are at increased risk of cognitive decline, since the metabolic and vascular disturbances of the disease affect brain function. Additionally, prolonged exposure to olther potential detrimental factors leads to irreversible cognitive decrements over time due to the aging process. Neurocognitive impairment signifies decreased performance in cognitive domains such as verbal and nonverbal memory, both immediate and delayed memory, executive function, attention, visuospatial and psychomotor performance, information processing speed, semantic knowledge, and language abilities. The aim of the present article is to review the existing literature on the issue of the neurocognitive decline in type 2 diabetes. A literature search of databases was performed, using as keywords "diabetes" and "cognitive impairment," and the reference list of papers so identified were examined, with only English language papers being used. Understanding and preventing diabetes-associated cognitive deficits remains a key priority for future research. It is important to ascertain whether interventions to delay diabetes onset or better control of established disease could prevent some of its adverse effects on cognitive skills.
有新的证据表明，认知障碍可能是糖尿病相关的并发症。有人认为，糖尿病患者认知能力下降的风险增加，因为疾病的代谢和血管紊乱会影响大脑功能。此外，由于衰老过程，长时间暴露于其他潜在的有害因素会导致认知能力不可逆转的下降。神经认知障碍意味着认知领域的表现下降，如言语和非言语记忆、即时和延迟记忆、执行功能、注意力、视空间和心理运动表现、信息处理速度、语义知识和语言能力。本文的目的是综述 2 型糖尿病神经认知衰退的现有文献。通过数据库进行文献检索，使用的关键词是“糖尿病”和“认知障碍”，并对如此确定的论文参考文献进行了检查，只使用了英语论文。了解和预防与糖尿病相关的认知缺陷仍然是未来研究的一个关键重点。重要的是要确定是否有干预措施可以延迟糖尿病的发病或更好地控制已确诊的疾病，从而预防其对认知技能的一些不良影响。
