Akbari Hossein, Hooshyar Zahra, Shabanitabar Saeede, Salmani Ali, Nikoueinejad Hassan, Einollahi Behzad
Social Determinants of Health (SDH) Research Center, Department of Biostatistics and Epidemiology, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Iran J Allergy Asthma Immunol. 2019 Aug 17;18(4):412-418. doi: 10.18502/ijaai.v18i4.1419.
Delayed graft function (DGF) is a transplant complication which means a need to dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between the two immunomodulatory factors of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble fibrinogen-like protein 2 (sFGL-2) with DGF after transplantation. This case-control study was done in 2 groups of 58 kidney transplant patients with and without DGF. The control group included the patients who didn't show DGF symptoms. Then, serum levels of sFlt-1and sFGL-2 in all blood samples were measured by ELISA. Serum sFlt-1 and sFGL-2 levels were significantly higher in the DGF group compared to those in the control group (p≤0.001). sFlt-1 and sFGL-2 serum levels significantly affect DGF (p<0.001) in such a way that they may be diagnostic factors of DGF. This study showed a significant relationship between sFlt-1 as well as sFGL-2 and DGF. Therefore, plasma levels of sFlt-1 and sFGL-2 may be used as diagnostic tools to determine the risk of DGF.
移植肾功能延迟恢复（DGF）是一种移植并发症，指在移植后的第一周内需要进行透析。本研究旨在确定可溶性fms样酪氨酸激酶-1（sFlt-1）和可溶性纤维蛋白原样蛋白2（sFGL-2）这两种免疫调节因子与移植后DGF之间的关系。这项病例对照研究在两组各58例有或无DGF的肾移植患者中进行。对照组包括未出现DGF症状的患者。然后，通过酶联免疫吸附测定法（ELISA）测量所有血样中sFlt-1和sFGL-2的血清水平。与对照组相比，DGF组的血清sFlt-1和sFGL-2水平显著更高（p≤0.001）。sFlt-1和sFGL-2血清水平以可能成为DGF诊断因素的方式显著影响DGF（p<0.001）。本研究表明sFlt-1以及sFGL-2与DGF之间存在显著关系。因此，sFlt-1和sFGL-2的血浆水平可作为确定DGF风险的诊断工具。
