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阻塞性睡眠呼吸暂停的围手术期处理。

Perioperative considerations in the management of obstructive sleep apnoea.

机构信息

Royal Melbourne Hospital, Melbourne, VIC.

Peter MacCallum Cancer Centre, Melbourne, VIC.

出版信息

Med J Aust. 2019 Oct;211(7):326-332. doi: 10.5694/mja2.50326. Epub 2019 Sep 15.

Abstract

Obstructive sleep apnoea (OSA) is characterised by repetitive compromise of the upper airway, causing impaired ventilation, sleep fragmentation, and daytime functional impairment. It is a heterogeneous condition encompassing different phenotypes. The prevalence of OSA among patients presenting for elective surgery is growing, largely attributable to an increase in age and obesity rates, and most patients remain undiagnosed and untreated at the time of surgery. This condition is an established risk factor for increased perioperative cardiopulmonary morbidity, heightened in the presence of concurrent medical comorbidities. Therefore, it is important to perform preoperative OSA screening and risk stratification - using the STOP-Bang screening questionnaire, nocturnal oximetry, and ambulatory and in-laboratory polysomnography, for example. Postoperative risk assessment is an evolving process that encompasses evaluation of upper airway compromise, ventilatory control instability, and pain-sedation mismatch. Optimal postoperative OSA management comprises continuation of regular positive airway pressure, a multimodal opioid-sparing analgesia strategy to limit respiratory depression, avoidance of supine position, and cautious intravenous fluid administration. Supplemental oxygen does not replace a patient's regular positive airway pressure therapy and should be administered cautiously to avoid risk of hypoventilation and worsening of hypercapnia. Continuous pulse oximetry monitoring with specified targets of peripheral oxygen saturation measured by pulse oximetry is encouraged.

摘要

阻塞性睡眠呼吸暂停(OSA)的特征是上呼吸道反复受阻,导致通气受损、睡眠碎片化和白天功能障碍。它是一种异质性疾病,包含不同的表型。在接受择期手术的患者中,OSA 的患病率不断增加,这主要归因于年龄和肥胖率的上升,而且大多数患者在手术时仍未被诊断和治疗。这种情况是围手术期心肺发病率增加的既定危险因素,如果同时存在合并症则更为明显。因此,进行术前 OSA 筛查和风险分层非常重要——例如,可以使用 STOP-Bang 筛查问卷、夜间血氧测定、动态和实验室多导睡眠图。术后风险评估是一个不断发展的过程,包括对上气道阻塞、通气控制不稳定和疼痛-镇静不匹配的评估。最佳的术后 OSA 管理包括继续常规使用正压通气、采用多模式阿片类药物节约镇痛策略以限制呼吸抑制、避免仰卧位以及谨慎给予静脉输液。补充氧气不能替代患者的常规正压通气治疗,应谨慎给予,以避免低通气和高碳酸血症恶化的风险。建议使用连续脉搏血氧监测仪监测外周血氧饱和度,并设定脉搏血氧饱和度的目标值。

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