Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, South Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, Republic of Korea.
Clin Rheumatol. 2020 Jan;39(1):159-166. doi: 10.1007/s10067-019-04769-x. Epub 2019 Sep 16.
The present study evaluated the associations between rheumatoid arthritis (RA) and neurodegenerative dementia using a Korean national sample cohort.
We designed two studies using the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Study I included participants with dementia matched 1:4 with controls and analyzed the participants' history of RA. Study II included participants with RA matched 1:4 with controls and analyzed the occurrence of dementia. RA was defined by the presence of relevant ICD-10 codes (M05 or M06) and medication histories. Neurodegenerative dementia was defined using ICD-10 codes (G30 or F00). Crude and adjusted odds ratios (ORs) were analyzed using conditional logistic regression analyses. Crude and adjusted hazard ratios (HRs) were analyzed using the stratified Cox proportional hazard model. Subgroup analyses were performed on groups stratified by age and sex.
The adjusted ORs for RA were 0.96 (95% CI = 0.78-1.16, P = 0.644) in the dementia group in study I. The adjusted HRs for dementia were 0.91 (95% CI = 0.76-1.10, P = 0.319) in the RA group in study II. No subgroup analysis reached the statistical significance level.
We could not identify any significant relationship between RA and dementia.Key Points• Two studies were conducted to identify the relationship between rheumatoid arthritis and dementia using national cohort data.• Neither study showed any association between rheumatoid arthritis and dementia.
本研究使用韩国全国样本队列评估类风湿关节炎（RA）与神经退行性痴呆之间的关联。
我们使用韩国国家健康保险服务-国家样本队列（2002 年至 2013 年）设计了两项研究。研究 I 纳入了痴呆症患者，并与对照组进行 1:4 匹配，分析了参与者的 RA 病史。研究 II 纳入了 RA 患者，并与对照组进行 1:4 匹配，分析了痴呆症的发生情况。RA 通过存在相关的 ICD-10 编码（M05 或 M06）和药物治疗史来定义。神经退行性痴呆使用 ICD-10 编码（G30 或 F00）来定义。使用条件逻辑回归分析分析了 RA 的粗和调整后的优势比（OR）。使用分层 Cox 比例风险模型分析了 RA 的粗和调整后的风险比（HR）。进行了按年龄和性别分层的亚组分析。
在研究 I 中，痴呆症组的 RA 的调整后 OR 为 0.96（95%CI=0.78-1.16，P=0.644）。在研究 II 中，RA 组发生痴呆症的调整后 HR 为 0.91（95%CI=0.76-1.10，P=0.319）。没有亚组分析达到统计学显著性水平。
我们无法确定 RA 与痴呆症之间存在显著关系。
进行了两项研究，使用全国队列数据来确定类风湿关节炎和痴呆之间的关系。
两项研究均未显示类风湿关节炎与痴呆症之间存在任何关联。
