急性淋巴细胞白血病患儿在细胞毒性治疗期间脑电图背景活动的变化

Changes in the EEG background activity of children with acute lymphoblastic leukemia during cytotoxic therapy.

作者信息

Lichter-Konecki U, Benninger C, Brandeis W E, Matthis P, Scheffner D

机构信息

University Children's Hospital, University of Heidelberg, F.R.G.

出版信息

Pediatr Hematol Oncol. 1987;4(1):77-85. doi: 10.3109/08880018709141252.

DOI:10.3109/08880018709141252

PMID:3152916

Abstract

Thirteen children with acute lymphoblastic leukemia (ALL) were investigated before and during cytotoxic therapy. EEG findings were correlated with the clinical course and the therapy protocol and compared with normal data obtained from 295 healthy children. Frequency analysis of the background activity of the EEG revealed an initial slowing of the background activity prior to therapy and further slowing each time a combination of vincristine (VCR), daunorubicin (DAU) or adriblastine (ADR), prednisone (PRED), and L-asparaginase (L-ASP) was administered. The slowing of the background activity correlated only with the administration of these drugs. DAU, ADR, and PRED are not known to influence the EEG; therefore, VCR and L-ASP remain the primary candidates responsible for the central nervous system alteration.

摘要

对13名急性淋巴细胞白血病（ALL）患儿在细胞毒性治疗前和治疗期间进行了调查。脑电图（EEG）结果与临床病程和治疗方案相关，并与从295名健康儿童获得的正常数据进行比较。EEG背景活动的频率分析显示，治疗前背景活动最初减慢，每次给予长春新碱（VCR）、柔红霉素（DAU）或阿霉素（ADR）、泼尼松（PRED）和L-天冬酰胺酶（L-ASP）联合用药时进一步减慢。背景活动的减慢仅与这些药物的给药有关。已知DAU、ADR和PRED不会影响EEG；因此，VCR和L-ASP仍然是导致中枢神经系统改变的主要候选药物。