Schmiegelow K, Pulczynska M K, Seip M
Department of Pediatrics, University Hospital, Copenhagen, Denmark.
Pediatr Hematol Oncol. 1988;5(4):259-67. doi: 10.3109/08880018809037365.
In a retrospective study of 84 children with standard-risk acute lymphoblastic leukemia diagnosed in 1981-1986, mean white cell count (mWBC) during maintenance chemotherapy (MT) was found to be significantly related to risk of hematological relapse, giving patients with the higher mWBC the poorer outcome. The only other significant relapse-related risk factor was white-cell count at diagnosis. mWBC was not significantly related to white cell count at diagnosis, sex, age, or dose of methotrexate or mercaptopurine. Patients with low mWBC also had relatively low white-cell counts after cessation of therapy when compared with patients with high mWBC.
在一项对1981年至1986年确诊的84例标准风险急性淋巴细胞白血病儿童的回顾性研究中，发现维持化疗（MT）期间的平均白细胞计数（mWBC）与血液学复发风险显著相关，mWBC较高的患者预后较差。唯一另一个与复发显著相关的风险因素是诊断时的白细胞计数。mWBC与诊断时的白细胞计数、性别、年龄、甲氨蝶呤或巯嘌呤的剂量均无显著相关性。与mWBC较高的患者相比，mWBC较低的患者在治疗停止后白细胞计数也相对较低。
