M U Zaman, N Fatima, S U Mehdi, M Sami, Kh Khan, G Khan
PET/CT Imaging Services, Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan.
Allmed Solution, Karachi, Pakistan.
J Biomed Phys Eng. 2019 Aug 1;9(4):409-416. doi: 10.31661/jbpe.v0i0.792. eCollection 2019 Aug.
Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for FDG-based PET/CT clinical imaging. We are sharing our experience of BG-75 in the first year (December 2015-November 2016) after commissioning.
BG-75 Generator (ABT, USA) was installed in available space without major design modification. It has a self-shielded mini-cyclotron (7.5 MeV proton beam, positive ion with current < 5µA) to produce [F]F-, an automated card-based radiochemistry module to produce FDG and automated QC module to perform tests upon each batch of FDG. Data were collected for yields of [F]F-, FDG, QC and radiation safety parameters.
Total 545 runs in 167 days (3±01 runs/day) were made. Average yield with 60 minute bombardment using 4.5 µA current was 37 mCi and 21 mCi for [F]F- and FDG, respectively. Total 29 runs had chemistry or QC failures and were discarded. Remaining 516 batches were used to perform imaging upon 1370 patients (8±03 patients/day). Radiation dose in BG-75 suite and effective doses to 02 operators were within statutory limits.
BG-75 Generator provides safe, dependable and sustainable supply of F-Fluoride for FDG and other low-volume clinical PET imaging. Its compactness and automation need minimal space and manpower. Radiation dose rate in cyclotron suite and personal dosimetry were also found within safe limits. Its Dose-on-Demand workflow offers a new concept of Personalized Dose Preparation which is currently not possible with a conventional cyclotron.
紧凑型回旋加速器正逐渐普及，以满足对正电子发射断层显像（PET）示踪剂的巨大当前需求。巴基斯坦卡拉奇的阿迦汗大学医院已购置了首台占地面积最小的用于基于氟代脱氧葡萄糖（FDG）的PET/CT临床成像的BG - 75发生器。我们正在分享调试后第一年（2015年12月 - 2016年11月）使用BG - 75的经验。
BG - 75发生器（美国ABT公司）安装在可用空间内，无需进行重大设计修改。它有一个自屏蔽微型回旋加速器（7.5兆电子伏特质子束，电流＜5微安的正离子）来产生氟离子（[F]F - ），一个基于卡片的自动化放射化学模块来生产FDG，以及一个自动化质量控制模块对每批FDG进行测试。收集了氟离子（[F]F - ）、FDG的产量、质量控制和辐射安全参数的数据。
在167天内共运行了545次（每天3±0.1次）。使用4.5微安电流轰击60分钟时，氟离子（[F]F - ）和FDG的平均产量分别为37毫居里和21毫居里。共有29次运行出现化学或质量控制故障而被丢弃。其余516批次用于对1370名患者进行成像（每天8±0.3名患者）。BG - 75机房的辐射剂量以及两名操作人员的有效剂量均在法定限值内。
BG - 75发生器为FDG及其他小剂量临床PET成像提供安全、可靠且可持续的氟 - 氟化物供应。其紧凑性和自动化所需空间和人力极少。回旋加速器机房的辐射剂量率和个人剂量测定也在安全限值内。其按需给药工作流程提供了个性化剂量制备的新概念，这是传统回旋加速器目前无法实现的。
