2型糖尿病患者血清膜联蛋白V和抗膜联蛋白V水平及其与代谢参数的关系。

Serum Annexin V and Anti-Annexin V levels and their relationship with metabolic parameters in patients with type 2 diabetes.

作者信息

Bilgir Oktay, Vural Huseyin Afsin, Bilgir Ferda, Akan Ozden Yildirim, Demir Ismail

机构信息

. Izmir Bozyaka Training and Research Hospital, Department of Internal Medicine, Bozyaka, Izmir, Turkey.

. Katip Celebi University Medical School, Ataturk Education and Research Hospital Department of Allergy and Immunology, Izmir, Turkey.

出版信息

Rev Assoc Med Bras (1992). 2019 Sep 12;65(8):1042-1047. doi: 10.1590/1806-9282.65.8.1042.

DOI:10.1590/1806-9282.65.8.1042

PMID:31531599

Abstract

BACKGROUND

We investigated the serum annexin V and anti-annexin V levels and their relationship with metabolic parameters in patients recently diagnosed type 2 diabetic.

METHODS

A total of 143 patients recently diagnosed type 2 diabetes and 133 control subjects were included in the study. Body mass index (BMI), hs-CRP, HOMA-IR, carotid intima-media thickness, and serum levels of annexin V and anti-annexin V were investigated.

RESULTS

HOMA-IR, serum hs-CRP, and carotid intima-media thickness were found to be statistically significant. The Pearson correlation analysis revealed a statistically significant positive relationship between the carotid intima-media thickness and the annexin V level (r=0.29, p=0.006*). A statistically significant positive relationship was also detected between the Annexin V level and level of serum hs-CRP (r=0.29 p=0.006*).

CONCLUSION

A positive relationship was observed between the carotid intima-media thickness and annexin V at the end of our investigation. In this regard, we also believe that serum levels of annexin V may be increased for cardiovascular protection in the elevation of carotid intima-media thickness.

摘要

背景

我们研究了近期诊断为2型糖尿病患者的血清膜联蛋白V和抗膜联蛋白V水平及其与代谢参数的关系。

方法

本研究共纳入143例近期诊断为2型糖尿病的患者和133例对照者。对体重指数（BMI）、高敏C反应蛋白（hs-CRP）、稳态模型评估的胰岛素抵抗指数（HOMA-IR）、颈动脉内膜中层厚度以及膜联蛋白V和抗膜联蛋白V的血清水平进行了研究。

结果

发现HOMA-IR、血清hs-CRP和颈动脉内膜中层厚度具有统计学意义。Pearson相关性分析显示，颈动脉内膜中层厚度与膜联蛋白V水平之间存在统计学意义的正相关（r=0.29，p=0.006*）。膜联蛋白V水平与血清hs-CRP水平之间也检测到统计学意义的正相关（r=0.29，p=0.006*）。