Department of Internal Medicine, Ankara Kecioren Egitim ve Arastirma Hastanesi, Ankara, Turkey.
Department of Obstetrics and Gynecology, Ankara Kecioren Egitim ve Arastirma Hastanesi, Ankara, Turkey.
Gynecol Endocrinol. 2020 May;36(5):413-416. doi: 10.1080/09513590.2019.1666817. Epub 2019 Sep 18.
Physiological changes in hormone levels occur in thyroid gland during pregnancy. Screening of the thyroid hormone levels and determining trimester-specific reference intervals in pregnancy are important. Guidelines recommend the use of trimester-specific reference ranges for each country. The aim of this study is to determine trimester-specific thyroid function reference intervals for pregnancy in Turkish population. In total, 5000 patients were screened out of which 1258 patients have all of fT3, fT4 and TSH levels measured, were included in the study. Patients were grouped as follows: 482 women were in first trimester, 361 women were in second trimester, and 415 women were in third trimester. All analyses were performed by means of chemiluminescence methods (Liaison; DiaSorin S.p.A., Saluggia, Italy). The TSH reference intervals were 0.005-3.65, 0.01-3.63, and 0.2-3.46 mIU/L at the first, the second, and the third trimesters of pregnancy, respectively. The fT4 reference intervals were 0.72-1.79, 0.71-1.26, and 0.65-1.12 ng/dL at the first, the second, and the third trimesters, respectively. The fT3 reference intervals were 2.45-4.03, 2.37-3.85, and 2.31-3.77 ng/dL at the first, the second, and the third trimesters, respectively. It is crucial to determine population- and gestational-specific reference intervals for trustworthy treatment of pregnants.
在怀孕期间，甲状腺激素水平会发生生理变化。筛查甲状腺激素水平并确定妊娠特定的参考区间非常重要。指南建议每个国家都使用妊娠特定的参考范围。本研究旨在确定土耳其人群妊娠特定的甲状腺功能参考区间。总共筛选出 5000 名患者，其中 1258 名患者的 fT3、fT4 和 TSH 水平全部测量，被纳入研究。患者分为以下三组：482 名女性处于第一孕期，361 名女性处于第二孕期，415 名女性处于第三孕期。所有分析均采用化学发光法（Liaison；DiaSorin S.p.A.，意大利 Saluggia）进行。妊娠第一、二、三期的 TSH 参考区间分别为 0.005-3.65、0.01-3.63 和 0.2-3.46 mIU/L。fT4 的参考区间分别为 0.72-1.79、0.71-1.26 和 0.65-1.12 ng/dL。fT3 的参考区间分别为 2.45-4.03、2.37-3.85 和 2.31-3.77 ng/dL。为了可靠地治疗孕妇，确定人群和妊娠特异性参考区间至关重要。
