Becton D L, Friedman H S, Kurtzberg J, Chaffee S, Falletta J M, Kinney T R
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710.
Pediatr Hematol Oncol. 1986;3(3):259-65. doi: 10.3109/08880018609031225.
Mycoplasma pneumoniae, which usually causes mild infections in normal children, has been shown to cause isolated cases of severe pneumonia in children with sickle cell disease. We recently observed an outbreak of Mycoplasma pneumonia in three sisters with homozygous sickle cell disease. Two of them required hospitalization, and one progressed to respiratory failure requiring prolonged ventilatory assistance. All eventually recovered without long-term pulmonary complications. Familial outbreaks are not uncommon in Mycoplasma infection, but they have not been described previously in siblings with sickle cell disease. It is assumed that local or systemic host defense abnormalities predispose patients with sickling syndromes to more severe courses of Mycoplasma infections.
肺炎支原体通常在正常儿童中引起轻度感染，但已证实它可在镰状细胞病患儿中导致个别严重肺炎病例。我们最近观察到3名患有纯合子镰状细胞病的姐妹爆发了肺炎支原体感染。其中2人需要住院治疗，1人进展为呼吸衰竭，需要长期通气支持。所有人最终均康复，未出现长期肺部并发症。支原体感染中家族性爆发并不罕见，但此前在患有镰状细胞病的兄弟姐妹中尚未有过描述。据推测，局部或全身宿主防御异常使镰状细胞综合征患者更易发生严重的支原体感染病程。
