Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shanxi 710071, China.
Biomater Sci. 2019 Nov 1;7(11):4558-4567. doi: 10.1039/c9bm00853e. Epub 2019 Sep 18.
In this research, a degradable uniform mesoporous platform was designed as an imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) agent. FeO nanoparticles were prepared using the solvothermal method, and a layer of mesoporous SiO was coated onto them using sol-gel and etching processes, then these ultra-small up-conversion nanoparticles (UCNPs) were loaded into the porous structure through electrostatic conjunction and physical absorption. By adjusting the etching processes, FeO@mSiO and mSiO with a high surface area as a carrier host could be obtained separately. Importantly, the platform could recognize the tumor cells with a magnetic-response and then present strong photoacoustic (PA) and up-conversion luminescence (UCL) signals, and FeO@mSiO as drug carriers could be degraded by hydrolysis. Furthermore, under a single 808 nm laser, the temperature of FeO@mSiO@UCNPs rises much higher than that of the surrounding tissues, and produces a large amount of singlet oxygen because a strong crossover occurs between the emitted blue emission of the UCNPs and the absorbance region of FeO. Therefore, the FeO@mSiO@UCNPs can be used as a magnetic-targeted dual-modal imaging guided PTT/PDT theranostic probe.
在这项研究中，设计了一种可降解的均匀介孔平台作为成像引导的光热治疗（PTT）/光动力治疗（PDT）剂。采用溶剂热法制备了FeO 纳米粒子，然后使用溶胶-凝胶和蚀刻工艺在其上涂覆一层介孔 SiO，然后通过静电结合和物理吸附将这些超小上转换纳米粒子（UCNPs）装入多孔结构中。通过调整蚀刻工艺，可以分别获得具有高表面积的 FeO@mSiO 和 mSiO 作为载体主体。重要的是，该平台可以识别具有磁响应的肿瘤细胞，然后呈现出强烈的光声（PA）和上转换发光（UCL）信号，并且 FeO@mSiO 作为药物载体可以通过水解降解。此外，在单个 808nm 激光下，FeO@mSiO@UCNPs 的温度比周围组织升高得更高，并且因为 UCNPs 的发射蓝光发射与 FeO 的吸收区域之间发生强烈的交叉，所以会产生大量的单线态氧。因此，FeO@mSiO@UCNPs 可用作磁靶向双模式成像引导的 PTT/PDT 治疗探针。
