Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Immunity. 2019 Sep 17;51(3):418-420. doi: 10.1016/j.immuni.2019.08.016.
Factors regulating the differentiation of tissue-resident memory T (T) cells and tumor-infiltrating lymphocytes (TILs) are incompletely understood. In this issue of Immunity, Li et al. identify Bhlhe40 as a transcriptional regulator of CD8 T cell and TIL persistence and activity by orchestrating metabolic and epigenetic programming.
调控组织驻留记忆 T（T）细胞和肿瘤浸润淋巴细胞（TIL）分化的因素尚不完全清楚。在本期《免疫》杂志上，Li 等人通过协调代谢和表观遗传编程，确定 Bhlhe40 是 CD8 T 细胞和 TIL 持久性和活性的转录调节因子。
