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纳武利尤单抗诱导的转移性肾细胞癌患者腹腔样小肠病:病例报告及文献复习

Nivolumab-induced celiac-like enteropathy in patient with metastatic renal cell carcinoma: Case report and review of the literature.

作者信息

Duval Lucie, Habes Sarah, Chatellier Thierry, Guerzider Pascale, Bossard Céline, Masliah Claude, Archambeaud Isabelle, Touchefeu Yann, Matysiak-Budnik Tamara

机构信息

IMAD, Hepato-Gastroenterology & Digestive Oncology Hôtel Dieu, CHU de Nantes Nantes France.

University of Nantes Nantes France.

出版信息

Clin Case Rep. 2019 Jul 28;7(9):1689-1693. doi: 10.1002/ccr3.2342. eCollection 2019 Sep.

Abstract

Nivolumab may induce severe celiac-like enteropathy, that may appear very rapidly, after only two injections of nivolumab, and may be successfully treated with corticosteroids. This observation underlines the importance of histological analysis of duodenal biopsies and the necessity to rule out a real celiac disease in patients with nivolumab-induced diarrhea.

摘要

纳武利尤单抗可能会诱发严重的乳糜泻样肠病,这种病可能在仅注射两次纳武利尤单抗后就迅速出现,并且可用皮质类固醇成功治疗。这一观察结果强调了十二指肠活检组织学分析的重要性,以及在纳武利尤单抗诱发腹泻的患者中排除真正乳糜泻的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54e4/6745396/217ac75e1b01/CCR3-7-1689-g001.jpg

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