Thacker J, Stretch A, Stephens M A
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Aug;36(2):137-48. doi: 10.1080/09553007914550891.
Inactivation and mutation to thioguanine-resistance of V79 hamster cells were studied after irradiation with accelerated helium, boron or nitrogen ions covering a range of linear energy transfer from 28 to 470 keV micrometers-1. For all radiation qualities a dose-dependent increase in mutant frequency was found for doses giving surviving fractions greater than about 0.20. The effectiveness per unit dose for both inactivation and mutation induction increased with the linear energy transfer of the radiation to a maximum in the range 90-200 keV micrometer-1. However, the maximum mutagenic effectiveness relative to gamma-rays was about two or more times that for inactivation. It is suggested that a proportion of the radiation-induced mutants suffer extensive genetic damage, and that some forms of this damage may be induced with high efficiency by radiations of high linear energy transfer.
在用线性能量转移范围为28至470 keV·μm⁻¹的加速氦离子、硼离子或氮离子辐照后，研究了V79仓鼠细胞对硫鸟嘌呤的失活和抗性突变。对于所有辐射品质，当存活分数大于约0.20的剂量时，发现突变频率呈剂量依赖性增加。失活和突变诱导的单位剂量有效性随辐射的线性能量转移增加，在90 - 200 keV·μm⁻¹范围内达到最大值。然而，相对于γ射线的最大诱变有效性约为失活有效性的两倍或更多倍。有人提出，一部分辐射诱导的突变体遭受广泛的遗传损伤，并且这种损伤的某些形式可能由高线性能量转移的辐射高效诱导。
