催化串联 F-C 烷基化/C4-C3 环收缩反应：一种高效合成吲哚基环丙甲酰醛和酮的方法。
Catalytic Tandem Friedel-Crafts Alkylation/C4-C3 Ring-Contraction Reaction: An Efficient Route for the Synthesis of Indolyl Cyclopropanecarbaldehydes and Ketones.
机构信息
Dipartimento di Scienze Chimiche e Geologiche , Università degli Studi di Cagliari , S.S. 554, bivio per Sestu , 09042 Monserrato (CA) , Italy.
Dipartimento di Scienze della Vita e dell'Ambiente , Università degli Studi di Cagliari , via Ospedale 82 , 09124 Cagliari , Italy.
出版信息
Org Lett. 2019 Sep 20;21(18):7329-7332. doi: 10.1021/acs.orglett.9b02617. Epub 2019 Sep 6.
A general strategy for the synthesis of indolyl cyclopropanecarbaldehydes and ketones via a Brønsted acid-catalyzed indole nucleophilic addition/ring-contraction reaction sequence has been exploited. The procedure leads to a wide panel of cyclopropyl carbonyl compounds in generally high yields with a broad substrate scope.
一种通过 Brønsted 酸催化吲哚亲核加成/环缩合反应序列合成吲哚基环丙基甲酰醛和酮的通用策略已经被开发出来。该方法以广泛的底物范围，通常高产率得到一系列的环丙基羰基化合物。
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