Department of Oncology, Krakow University Hospital, 10 Sniadeckich St., 31-531, Krakow, Poland.
Department of Pathophysiology, Jagiellonian University Medical College, 18 Czysta St., 31-121, Krakow, Poland.
Peptides. 2019 Dec;122:170148. doi: 10.1016/j.peptides.2019.170148. Epub 2019 Sep 18.
Physiological roles of enterohormones such as secretion, absorption and digestion were supported by clinical data. Overexpression of cholecystokinin (CCK), neurotensin (NT) and vasoactive intestinal peptide (VIP) receptors occur in gastrointestinal (GI) malignancies. The aim of the paper was to compare plasma levels of CCK, peptide YY (PYY), VIP and NT in patients with gastrointestinal malignancies and healthy controls. The study included 80 patients (37 men and 43 women) with GI malignancies (20 with gastric and 60 with colorectal cancers). Median age of the patients was 62.9 years (range: 40-85 years). Control group was comprised of 30 healthy persons with median age 59.8 years (range: 40-82 years). Fasting plasma concentrations of CKK, PYY, NT, and VIP were determined at rest, using ELISA kits for automated systems. Comparative analysis of enterohormone levels in patients with various types of gastrointestinal malignancies demonstrated presence of some cancer-specific alterations. Patients with gastric cancers presented with lower plasma concentrations of CCK than healthy controls and individuals from colorectal cancers (p = 0.02). The highest plasma concentrations of neurotensin was found in colorectal cancer patients in comparison to gastric (p = 0.02). The plasma levels of VIP observed in gastric cancer group were lower than in colorectal cancer patients (p = 0.01). Patients with GI malignancies may present with tumor-specific alterations in plasma enterohormone levels.
肠激素（如分泌、吸收和消化）的生理作用得到了临床数据的支持。胆囊收缩素（CCK）、神经降压素（NT）和血管活性肠肽（VIP）受体在胃肠道（GI）恶性肿瘤中过度表达。本文旨在比较胃肠道恶性肿瘤患者和健康对照者血浆中 CCK、肽 YY（PYY）、VIP 和 NT 的水平。研究纳入 80 例胃肠道恶性肿瘤患者（男 37 例，女 43 例），包括 20 例胃癌和 60 例结直肠癌。患者的中位年龄为 62.9 岁（范围：40-85 岁）。对照组由 30 名健康人组成，中位年龄为 59.8 岁（范围：40-82 岁）。使用 ELISA 试剂盒，在空腹状态下，通过自动化系统测定 CKK、PYY、NT 和 VIP 的血浆浓度。对不同类型胃肠道恶性肿瘤患者肠激素水平的比较分析表明存在一些肿瘤特异性改变。与健康对照组和结直肠癌患者相比，胃癌患者的 CCK 血浆浓度较低（p=0.02）。与胃癌患者相比，结直肠癌患者的神经降压素血浆浓度最高（p=0.02）。与结直肠癌患者相比，胃癌患者的 VIP 血浆水平较低（p=0.01）。胃肠道恶性肿瘤患者可能存在血浆肠激素水平的肿瘤特异性改变。
